摘要
目的:检测大肠癌组织中Mina53与Mel-18蛋白的表达。方法:采用免疫组化法分别检测60例大肠癌及相应癌旁正常大肠黏膜组织中Mina53与Mel-18蛋白的表达。结果:大肠癌及相应癌旁正常大肠黏膜组织中Mina53蛋白的阳性表达率分别为60.0%和0%,Mel-18蛋白的阳性表达率分别为31.7%和61.7%,2组间相比差异均有统计学意义(χ2=34.028、7.043,P均<0.05)。大肠癌组织中Mina53、Mel-18蛋白的表达与患者的性别、年龄无关(P均>0.05),而与肿瘤的浸润深度、淋巴结转移及分化程度有关(P均<0.05)。大肠癌组织中Mina53与Mel-18蛋白的表达呈负关联(r P=-0.557,P<0.001)。结论:Mina53与Mel-18的异常表达可能在大肠癌的发生发展中起重要作用。
Aim：To investigate the expressions of Mina53 and Mel-18 proteins in colorectal carcinoma tissue. Methods：The expressions of Mina53 and Mel-18 proteins were detected by immunohistochemistry in 60 colorectal carcinoma specimens and 60 normal colorectal mucosa specimens. Results：The positive expression rate of Mina53 in colorectal carcinoma and normal colorectal mucosa tissue was 60. 0% and 0%,and that of Mel-18 was 31. 7% and 61. 7%,and there were significant differences（ χ2= 34. 028,7. 043,P 0. 05）. The expressions of Mina53 and Mel-18 proteins were associated with tumor infiltration depth,lymph node metastasis and tumor differentiation in colorectal carcinoma（ P 0. 05）,but not with age or gender（ P 0. 05）. A negative association was noted between the expression of Mina53 and that of Mel-18in colorectal carcinoma tissue（ r P=- 0. 557,P 0. 001）. Conclusion：The imbalance of Mina53 and Mel-18 expression may play an important role in the carcinogenesis and development of colorectal carcinoma.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2013年第6期780-783,共4页
Journal of Zhengzhou University(Medical Sciences)
