摘要
目的探讨氯吡格雷抵抗与择期冠状动脉介入术后缺血性事件发生的相关性。方法选取60例择期冠状动脉介入术患者，在服用氯吡格雷前及术后5d血小板聚集率前后差值分组，第1组差值≤10％（氯吡格雷抵抗组），第2组差值介于10％～20％，第3组差值≥20％。结果冠状动脉介入术后5d有13％的患者存在氯吡格雷抵抗现象。在术后6个月的随访期内，第1组有37.5％的患者发生心脏缺血性事件。第2组有1例患者（3.5％）出现脑梗死，第3组无缺血性事件发生。结论部分择期冠状动脉介入术患者存在氯吡格雷抵抗现象，患者对氯吡格雷抵抗可能增加术后心脑血管缺血性事件发生的危险。
Objective To evaluate the prevalence of clopidogrel resistance and the risk of adverse ischemic events in the patients undergoing elective coronary stenting. Methods 60 elective percutaneous coronary intervention were chosen and takn clopidogrel, before and 5 days after the platelet aggregation rate difference before and after the grouping, difference between first groups （〈10% clopidogrel resistance group）, second groups of difference between 10% - 20%, difference between third groups of ≥20%. Results Percutaneous coronary intervention on postoperative day 5 and 13% of patients has the phenomenon of clopidogrel resistance. In June 2 in the follow-up period, 37.5% had cardiac ischemic events in patients with the first group. The second group of 1 patient （3.5%） experienced cerebral infarction, third groups had no ischemic events. Conclusion Some of patients undergoing elective coronary stenting are resistant to clopidogrel, and clopidogrel resistance may increase the risk of adverse ischemic events after stenting.
出处
《当代医学》
2013年第35期126-126,160,共2页
Contemporary Medicine
