摘要
目的 :评价马来酸氨氯地平片剂对原发性高血压患者的降压效应。并与苯磺酸氨氯地平片剂对照。方法 :原发性高血压患者 12 0例 ,采用临床多中心随机、单盲、对照实验设计 ,将患者分为对照组和实验组 ,分别服用苯磺酸氨氯地平 5～ 10mg/d ,疗程 4周和马来酸氨氯地平 5～ 10mg/d ,疗程 4周。于用药前、后分别测 2 4h动态血压、诊所血压及进行血液生化学检查。结果 :用药 4周后 ,两组降压总有效率分别为实验组 87% ,对照组 85 % ;对收缩压、舒张压的下降程度两组比较无统计学差异 (P >0 .0 5 ) ;降压谷 /峰比值 :实验组收缩压为 0 .80 ,舒张压为 0 .73 ,对照组收缩压为 0 .82 ,舒张压为 0 .75。表明马来酸氨氯地平与苯磺酸氨氯地平一样具有平稳降压作用 ;不良反应发生率两组相似 ,且多轻微 ,患者依从性好。结论 :马来酸氨氯地平对原发性高血压疗效确切 ,能平稳控制 2 4h血压 。
Objective:To evaluate the antihypertensive efficacy of amlodipine meleate in comparison with amlodipine benzene sulfonate.Methods:120 patients with essential hypertension were divided to receive 5～10 mg amlodipine maleate tablet or amlodipine benzene sulfonate tablet 5～10 mg for 4 weeks.Before and after treatment the 24h ambulatory BP and blood biochemical tests were examined.Results:No significant differences between groups were observed in all parameters including total effective rate,decrease of SBP and DBP,peak/trough ration of blood pressure with mild adverse reactions.Conclusion:Amlodipine maleate is an effective agent for treatment of essential hypertension. [
出处
《中国新药杂志》
CAS
CSCD
2000年第12期841-844,共4页
Chinese Journal of New Drugs
