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新辅助治疗在直肠癌综合性治疗模式中的应用

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摘要 目的探讨新辅助治疗在直肠癌综合性治疗模式中的应用价值。方法回顾性分析38例Ⅱ-Ⅲ期中低位直肠癌患者采用新辅助治疗的临床资料。术前采用新辅助放疗总剂量为45.0-50.4Gy,同步化疗为卡培他滨口服。新辅助治疗结束后4-6周进行手术治疗。结果新辅助治疗后,35例行根治性手术,3例行单纯造瘘术。完全缓解率为5.3%(2/38),总有效率为50.0%(19/38)。术后并发症:会阴部感染3例,骶尾部疼痛5例,吻合口瘘2例。局部复发率2.9%(1/35)。结论采用新辅助治疗可以控制、减小直肠癌原发病灶,利于行根治性手术切除,且可减少局部复发率,不增加术后并发症的发生率。
出处 《江苏医药》 CAS 北大核心 2013年第23期2903-2904,共2页 Jiangsu Medical Journal
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参考文献10

  • 1杨平,彭翔,邓建中,程龙庆,周永辉,李志澄,朱佳成.直肠癌新辅助治疗后联合腹腔镜下全直肠系膜切除术44例[J].广东医学,2012,33(17):2586-2590. 被引量:34
  • 2邵永胜,张应天,彭开勤,胡赤丁,余阳,吴文良.局部进展期直肠癌新辅助化放疗的疗效观察[J].临床外科杂志,2011,19(2):104-106. 被引量:8
  • 3Deguehi Y, Endo S, Tanaka J, et al. A case or resection of synchronous multiple liver metastases from rectal cancer after FOLFOX4 therapy[J].Gan To Kagaku Ryoho, 2010,37 (6) : 1159-1162. 被引量:1
  • 4Roh MS, Colangelo LH, orConnell MJ, et al. Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03 [J]. J Clin Oncol,2009,27(31 ) :5124-5130. 被引量:1
  • 5Crane CH, Skibber JM, Feig BW, et al. Response to preopera- tive chemoradiation increases the use of sphincter preserving surgery in patients with locally advanced low rectal carcinoma [J]. Cancer,2003. 97(2) :517-524. 被引量:1
  • 6肖毅.直肠癌新辅助治疗[J].中国普外基础与临床杂志,2010,17(9):906-909. 被引量:11
  • 7Bosset JF,Collette L,Calais G, et al. Chemotherapy with pre operative radiotherapy in rectal eancer[J]. N Engl J Med, 2006,335(11) : 1114-1123. 被引量:1
  • 8Minsky BD, Cohen AM, Kemeny N, et al. Combined modality therapy of rectal cancer: decreased acute toxicity with the pre- operative approach [ J ]. J Clin Oncol, 1992, 10 ( 12 ) : 1218-1224. 被引量:1
  • 9彭开勤,邵永胜,张应天,胡赤丁,余阳,吴文良.直肠癌新辅助治疗与手术间隔时间对降期疗效的影响[J].国际外科学杂志,2011,38(8):511-514. 被引量:3
  • 10J eong DH, Lee HB, Hur tt, et al. Optimal timing of surgery after neoadjuvant ehemoradiation therapy in locally advanced rectal cancer[J].J Korean Surg Soc,2013,84(6) :338-345. 被引量:1

二级参考文献78

  • 1Higgins GA,Humphrey EW,Dwight RW,et al. Preoperative radiation and surgery for cancer of the rectum. Veterans Administration Surgical Oncology Group Trial Ⅱ[J].Cancer,1986; 58(2):352-359. 被引量:1
  • 2Gérard A,Buyse M,Nordlinger B,et al. Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC)[J].Ann Surg,1988; 208(5):606-614. 被引量:1
  • 3Hyams DM,Mamounas EP,Petrelli N,et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum:a progress report of National Surgical Breast and Bowel Project Protocol R-03[J].Dis Colon Rectum,1997; 40(2):131-139. 被引量:1
  • 4Medical Research Council Rectal Cancer Working Party. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cance[J].Lancet,1996; 348(9042):1605-1610. 被引量:1
  • 5Stockholm Colorectal Cancer Study Group. Randomized study on preoperative radiotherapy in rectal carcinoma[J].Ann Surg Oncol,1996; 3(5):423-430. 被引量:1
  • 6Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer[J].N Engl J Med,1997; 336(14):980-987. 被引量:1
  • 7Kapiteijn E,Marijnen CA,Nagtegaal ID,et al; Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer[J].N Engl J Med,2001; 345(9):638-646. 被引量:1
  • 8Mohiuddin M,Marks G. High dose preoperative irradiation for cancer of the rectum,1976-1988[J].Int J Radiat Oncol Biol Phys,1991; 20(1):37-43. 被引量:1
  • 9Janjan NA,Crane CN,Feig BW,et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer[J].Int J Radiat Oncol Biol Phys,2000; 47(3):713-718. 被引量:1
  • 10Sauer R,Becker H,Hohenberger W,et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J].N Engl J Med,2004; 351(17):1731-1740. 被引量:1

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