摘要
目的探讨临床缓解期溃疡性结肠炎(UC)患者健康相关生存质量(HRQoL)的变化及其影响因素。方法以2011年11月至2012年3月北京大学第一医院门诊缓解期UC患者为研究对象,其中临床缓解期UC患者42例,同时选取健康人50名作为对照组。记录包括性别、年龄、民族、婚姻、文化程度、医疗方式、吸烟、饮酒史等人口学资料以及病程、发病年龄等,填写简明健康调查问卷(SF36)、炎症性肠病生存质量相关量表(IBDQ)、服药依从性量表、医院焦虑抑郁量表焦虑分表及抑郁分表(HAD-A,HAD-D)。分析缓解期UC患者的HRQoL得分情况及影响因素。结果 (1)研究组IBDQ总分170.26±43.67,SF-36总分110.60±18.82,HAD-A 5.21±3.72,HAD-D4.79±3.81;对照组IBDQ总分210.54±7.30,SF-36总分123.48±8.68,HAD-A 3.14±1.40,HAD-D 3.42±1.84。研究组与对照组的SF-36、IBDQ总分及躯体健康和心理健康各维度得分差异均有统计学意义,且研究组焦虑抑郁得分较正常对照组明显升高,差异有统计学意义。(2)在人口学资料、疾病资料、服药依从性及焦虑抑郁状态因素中,病程、服药依从性及焦虑抑郁情绪是影响患者生存质量较为重要的因素,与IBDQ总分的相关系数分别为-0.354、0.355、-0.498;另外不同就医方式组间生存质量差异有统计学意义(P<0.05)。结论临床缓解期UC患者生存质量低于正常对照组,其焦虑抑郁情绪较正常人明显。病程长短、焦虑抑郁状态与患者的生存质量呈负相关,服药依从性越好,患者的生存质量越高。
Objective To investigate the health-related quality of life （HRQoL） of patients with ulcerative colitis （UC） in remission as well as its influencing factors. Methods A total of 42 UC patients in remission from the outpatient department and 50 controls from physical examination department of the First Hospital Peking University were enrolled in our study from November 2011 to March 2012. Demographic data collected included age, gender, marital status and smoking habits. Data regarding the disease included disease duration and so on. They were requested by fill in the Quality of Life Scales, Medication Compliance Scales,and Hospital Anxiety and Depression Scales （ HAD-A, HAD-D）. Results （ 1 ） The total score of IBDQ for the UC patients was 170. 26 ＋43.67,total score of SF-36 110. 60 ± 18.82,score of HDA-A 5.21 ±3.72,and score of HDA-D was 4. 79 ±3.81 ;while those scores for the controls were 210. 54 ±7.30,123.48 ±8.68,3.14 ±1.40 and 3.42 ±1.84 respectively. There were significant differences in the total scores of SF-36 and IBDQ between the two groups,and dimension scores,HAD-A,and HAD-D for the UC patients were much higher than those for the controls. （2） Among the data collected, course of disease, medication compliance, and status of anxiety and depression were much more important factors affecting HRQoL of the patients. Conclusion The quality of life for patients with UC in remission is lowered in the aspects of bowel symptoms, systemic symptoms, emotional function, and social function, and the scores for anxiety and depression scale of are significantly higher than normal individuals. The HRQoL of patients with UC in remission may be influenced by duration of disease, medication compliance and psychological factors. The better of the medication compliance is, the higher of the quality of life will be.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2013年第12期961-964,共4页
Chinese Journal of Practical Internal Medicine
关键词
溃疡性结肠炎
健康相关生存质量
服药依从性
ulcerative colitis
health-related quality of life
medication compliance
