摘要
目的探讨糖尿病肾病(DN)早期诊断中β2-微球蛋白(β2-MG)检测的临床价值。方法选取2012年1—8月确诊为DN患者80例为观察组,选取同期进行健康体检合格者80例为对照组,两组受试者均进行β2-MG检测,同时检测与肾功能评价密切相关的血清生化指标尿素(Urea)和肌酐(Cr)水平,并对结果进行综合分析。结果观察组β2-MG、Urea、Cr水平明显高于对照组,两组比较,差异有统计学意义(P<0.05);不同病期DN患者β2-MG呈递增性升高,Ⅱ、Ⅲ、Ⅳ期DN患者β2-MG水平明显高于Ⅰ期患者,差异有统计学意义(P<0.05),Ⅰ期DN患者β2-MG检测阳性率为88.5%,与同期Urea、Cr阳性检出率(53.8%、46.2%)比较,差异有统计学意义(P<0.05)。结论β2-MG是早期诊断DN的一项良好的血清生化指标,其水平变化可为临床诊治DN提供依据。
Objective To explore the application value of β2-microglobulin （β2-MG） for the early diagnosis of diabetic nephropathy（NG）. Methods 80 patients diagnosed with DN from January to August 2012 were selected as observation group, and 80 cases of healthy physical examines at the corresponding period were selected as control group. The respondents in both groups were taken β2-MG detection,meanwhile,the contents of Serum biochemical indicators including Urea and creatinine （Cr） ,which were closely related with the evaluation of renal function ,were detected. The results of the two groups were compre- hensively analyzed. Results The contents of β2-MG, Urea and Cr in the observation group were obviously higher than those in control group, and the difference between the two groups were statistically significant （P〈0.05）. The contents of β2-MG in the pa- tients with DN increased in different clinical stages, and the content of β2-MG in patients with DN in stage II , stage III and stage IV was Drominently higher than that in staged I with statistically significant difference （P〈0.05）. The positive of β2-MG in staged I was 88.5% ,compared with the positive detection rate of Urea and Cr（53.8% and 46.2% respectively） at the corresponding pe- riod,the difference had statistical significance （P〈0.05）. Conclusion β2-MG is a good serum biochemical indicator for early di- agnosis of DN, and the change of its contents can provide a basis for clinical diagnosis and treatment of DN.
出处
《现代医药卫生》
2013年第23期3542-3543,共2页
Journal of Modern Medicine & Health
关键词
Β2微球蛋白
肌酸酐
尿素
糖尿病肾病
早期诊断
Beta 2-microglobulin
Creatinine
Urea
Diabetic nephropathies
Early diagnosis
