摘要
目的：分析张家口地区真菌性角膜炎的病原学及流行病学特征，为其临床诊治提供一定的参考依据。方法：回顾性分析2010年12月-2012年6月我院收治的97例真菌性角膜炎患者的临床资料，分析其病原菌的构成、诊断方法及药物敏感性情况。结果：总共鉴定出84株真菌，分属12个属、23个种，其中以镰刀菌属感染最为多见（51．2％），其次为曲霉属（14．3％）和假丝酵母属（10．7％）；感染者以男性劳动者居多，外伤是最常见的诱因，秋冬季为高发季节；不同菌种对药物的敏感性存在区别，主要致病菌种对两性霉素B和纳他霉素的敏感性均达70％以上，较其它抗真菌药物高。结论：镰刀菌为本地区真菌性角膜炎的主要致病菌，病原体种类和构成与其他北方地区无明显区别。两性霉素B和纳他霉素为大多数菌种的敏感药物，可作为本地区临床预防和治疗的首选药物。
Objective： To analyze the etiology and epidemiological characteristics of fungal keratitis in Zhangjiakou, thus provide references for the clinical diagnosis and treatment of fungal keratitis. Methods： A retrospective study was carried Out in 97 patients diagnosed as fungal keratitis in our hospital from December 2010 to June 2012. The pathogen composition, diagnosis methods and drug sensitivity situation were analyzed. Results： 84 plants of fungi were identified and belonged to 12 genera, 23 kinds. Fusarium infection was the most common fungi （51.2%）, followed by Aspergillus （14.3%） and Candida （10.7%）; the majority infected person were male laborer, trauma was the most common susceptibility incentive. Autumn and Winter were the high-risk seasons. Drug sensitivity of different strains had difference, the main pathogenic bacteria＇s sensitivity to Amphotericin B and Natamycin were 〉70%, which was higher than other drugs. Conclusion： The Fusarium was the main fungal keratitis in zhangjiakou, pathogen species and composition had no obvious difference with other Northern region. Amphotericin B and Natamycin were the most sensitive drug, which can be used as the first choice to clinical prevention and treatment.
出处
《现代生物医学进展》
CAS
2013年第29期5779-5781,共3页
Progress in Modern Biomedicine
关键词
角膜炎
真菌
临床分析
流行病学
药物敏感性
Keratitis
Fungi
Clinical analysis
Epidemiology
Drug susceptibility
