改良VCTD方案治疗老年多发性骨髓瘤15例临床疗效观察
Clinical observation of modified VCTD regimen on 15 cases of elderly multiple myeloma
摘要
多发性骨髓瘤(multiplemyeloma,MM)是常见的造血系统恶性肿瘤之一,随着年龄的增长其发病数也增加,特别是70~80岁,甚至在大于80岁的老年人中发病更为集中。随着新药的不断开发和新治疗方法的改进,MM的疗效得到明显改善,特别是蛋白酶体抑制剂抗肿瘤新药硼替佐米的开发应用,以及免疫调节剂沙利度胺和雷利度胺的临床深入研究给MM患者带来希望。
出处
《临床血液学杂志》
CAS
2013年第6期798-799,共2页
Journal of Clinical Hematology
参考文献8
-
1张之南,沈悌.血液病诊断及疗效标准[M].3版.北京:北京科学出版社,2011:232-235. 被引量:1
-
2中国多发性骨髓瘤诊治指南(2011年修订)[J].中华内科杂志,2011,50(10):892-896. 被引量:111
-
3张立明.小剂量反应停联合大剂量地塞米松治疗多发性骨髓瘤40例[J].临床血液学杂志,2010,23(2):108-108. 被引量:2
-
4AHN J S,YANG D H,JUNG S H,et al. A compari- son of bortezomib, cyclophosphamide, and dexametha- sone (Vel-CD) chemotherapy without and with thalid- omide (Vel-CD) for the treatment of relapsed or re- fractory multiple myeloma EJ. Ann Hematol, 2012, 91 : 1023 - 1030. 被引量:1
-
5DE LA RUBIA J, SANZ M A. Treatment o{ multiple myeloma in the elderly: realities and hopesFJ. Leuk Lymphoma, 2011,52 : 9- 14. 被引量:1
-
6闫春梅,胡俊斌,陈燕,崔国惠.不同剂量硼替佐米治疗多发性骨髓瘤的临床研究[J].临床血液学杂志,2011,24(5):535-538. 被引量:12
-
7WANG Y, AI L, CUI G, et al. Once-versus twise-weekly Bortezomib induction therapy with dexamethasone in newly diagnosed multiple myeloma[-J. J Huazhong Univ Sci Technolog Med Sci,2012,32:495-450. 被引量:1
-
8MOORE S, ATWAL S, SACHCHIT HANANTH-AM S,et al. Weekly intranous bortezomib is effective and well tolerated in relapsed/refractory myelomaEJ]. Eur J Haematol, 2013,90. 420 - 425. 被引量:1
二级参考文献12
-
1OGAWA Y,TOBINAI K,OGURA M,et al. Phase I and II pharmacokinetic and pharmaeodynamic study of the proteasome inhibitor hortezomib in Japanese pa- tients with relapsed or refractory multiple myeloma[J]. Cancer Sci, 2008,99 :140- 144. 被引量:1
-
2RICHARDSON P G, BARLOQIE B, BERENSON J, et al. Extended follow-up of a phase II trial in re- lapsed, refractory multiple myeloma: final time-to-e- vent results from the SUMMIT trial [J]. Cancer, 2006,106:1316-1319. 被引量:1
-
3MARCO L, GLORIA P, SIMONE F, et at. Major tumor shrinking and persistent molecular remissionsafter consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma [J]. J Clin Oncol, 201 O, 28 : 2077 - 2084. 被引量:1
-
4DURIE B G, HAROUSSEAU J L, MIGUEL J S, et al. International uniform response criteria for multiple myeloma [J]. Leukemia, 2006,20 : 1467-1473. 被引量:1
-
5KYLE R A,RAJKUMAR S V. Drug therapy of mul- tiple myeloma [J]. N Engl J Med, 2004,351 : 1860 - 1873. 被引量:1
-
6HE1DER U,KAISER M, MULLER C, et al. Treat- ment of bortezomib increases osteoblast function in patients with multiple myel.oma[J]. Bl.ood, 2005,106 3457. 被引量:1
-
7ADAMS J. Proteasome inhibition in cancer., develop-ment of ps-341 [J]. Semin Oncol, 2001,28:613 - 619. 被引量:1
-
8MITSIADES N, MITSIADES C S, RICHARDSON P G,et al. The proteasome inhibitor PS2341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents : therapeutic applieations[J]. Blood, 2003,101 : 2377 - 2380. 被引量:1
-
9AGATHOCLEOUS A, ROHATINER A, RULE S, et al. Weekly versus twice weekly bortezomib given in conjunction with rituximab,in patients with recurrent follicular lymphoma, mantle cell lymphoma and Waldenstrom macroglobulinaemia[J]. Br J Haematol, 2010,151 : 1365- 2141. 被引量:1
-
10张之南,沈悌.血液病诊断及疗效标准[M].2版.北京:科学出版社,1999:228-236. 被引量:6
共引文献121
-
1张忆梓,侯健,韦苇,郭列平,石昊天,李璐,凌晨晖,周帆.血清神经元烯醇化酶活性对初发多发性骨髓瘤患者预后的影响[J].中华血液学杂志,2012,33(5):417-419. 被引量:4
-
2张路,李詝,林海荣,李剑.疑难病例析评第267例四肢麻木-肝脾肿大-M蛋白-腹水-黄疸[J].中华医学杂志,2012,92(22):1573-1575.
-
3裴仁治,唐善浩,马俊霞,张丕胜,刘旭辉,杜小红,陈哲,陈冬,沙科娅,曹俊杰,李双月.趋化因子及其受体与多发性骨髓瘤的预后关系[J].中华内科杂志,2012,51(10):798-799. 被引量:2
-
4张翔,叶宝东,周郁鸿.中医药联合造血干细胞移植治疗恶性血液病进展与思路[J].中华中医药学刊,2012,30(11):2525-2528. 被引量:3
-
5郝润英,张书霞,栗瑞敏,王菊美.影响多发性骨髓瘤疗效和预后的实验室指标分析[J].国际检验医学杂志,2012,33(23):2836-2837. 被引量:4
-
6谢伟成,程淑琴,林翠芳,谢碧霞.硼替佐米、地塞米松和沙利度胺(VDT)化疗方案治疗复发多发性骨髓瘤(MM)的疗效及安全性[J].中国医药导刊,2012,14(12):2149-2149. 被引量:2
-
7魏莉,黄莺,陈勤奋.大剂量地塞米松在血液系统疾病治疗中的应用[J].上海医药,2013,34(3):17-21. 被引量:4
-
8魏莉,黄莺,陈勤奋.大剂量地塞米松冲击治疗血液系统疾病患者的整体护理[J].上海医药,2013,34(3):22-25. 被引量:3
-
9黄樱硕,王翠英,熊梅,王宇朋,王梦然,刘彦,刘冬梅.多发性骨髓瘤合并右下腹巨大包块一例病例报道及文献复习[J].临床和实验医学杂志,2013,12(6):467-468.
-
10王婧.血液净化治疗多发性骨髓瘤并发肾衰竭患者的疗效观察[J].中国医学工程,2013,21(1):35-35.
-
1纪冬梅.沙利度胺联合化疗治疗多发骨髓瘤临床分析[J].中国社区医师(医学专业),2011,13(10):193-194. 被引量:1
-
2吕鸣,吕有灵,王磊,孔宪涛.不同临床期多发性骨髓瘤患者骨髓瘤克隆IgH基因重排研究[J].武警医学,1998,9(6):311-313. 被引量:3
-
3多发性骨髓瘤[J].现代临床医学生物工程学杂志,1999,5(3):229-231.
-
4叶琇锦.多发性骨髓瘤的预后分层及分层治疗进展[J].临床血液学杂志,2013,26(6):743-746.
-
5唐尚权,刘风琼,余涛,陈涛,敖华,赵有芳.以骨折为首发表现的骨髓瘤门诊漏诊16例分析[J].中国误诊学杂志,2008,8(1):117-118. 被引量:2
-
6耿传营,陈文明.新药时代初治多发性骨髓瘤患者临床获益与方案选择[J].中华血液学杂志,2013,34(4):297-298. 被引量:1
-
7梅振华,周丽萍,邹亮.多发性骨髓瘤并双侧卵巢浆细胞瘤1例[J].内科急危重症杂志,2012,18(5):317-318. 被引量:1
-
8高大,肖镇.血红蛋白和β2-MG及LDH对多发性骨髓瘤预后影响[J].内蒙古医学杂志,2013,45(1):92-93. 被引量:5
-
9安利,朱琳,补娟,张晓燕,富玲,王晓敏.21例伴髓外浸润的多发性骨髓瘤患者临床特征分析[J].中华临床医师杂志(电子版),2016,10(11):99-100.
-
10黄海汛,范海泉,陈铭,杨帆,刘江川.经皮椎体成形术治疗多发性骨髓瘤的临床疗效[J].脊柱外科杂志,2014,12(2):100-102. 被引量:4