摘要
目的分析妊娠中期进行产前诊断的高危孕妇羊水细胞染色体核型,了解此期异常核型出现的频率及类型。方法 6887例具备产前诊断指征的妊娠妇女,在知情选择的情况下行羊膜腔穿刺术及染色体核型检测。结果 6876例羊水细胞培养成功,成功率为99.84%(6876/6887)。在6876例羊水细胞培养成功的染色体核型中,检出异常核型107例,异常率为1.56%,常见核型为三体型,占异常核型47.66%。结论羊水细胞学检查作为一项产前诊断技术对于指导优生优育,降低缺陷儿的出生具有重要意义。
Objective ： To analysis the amniotic fluid cells chromosome karyotypes of high - risk pregnant women for prenatal diag- nosis and understand the frequencies and types of chromosomal abnormalities in the trimester period. Methods ： Fetal chromosomal kar- yotypes were examined in 6887 pregnant women with amniotie cell culture. We studied in abnormal rate of fetal chromosomal karyotypes, searched the distribution of chromosomal abnormalities. Results： The success rate of amniotic cell culture was 99. 84% （6876/6887）. One hundred and seven cases chromosomal aberrations were detected in 6876 cases and the abnormal rate was 1.56%. Of which, 51 cases were trisomy （47.66% , 51/107 ）. Conclusions： As a prenatal diagnostic techniques for guiding prenatal, postnatal care and reducing birth defects in children, amniotic fluid cytology is very important.
出处
《中国优生与遗传杂志》
2013年第12期69-70,共2页
Chinese Journal of Birth Health & Heredity
基金
广西卫生厅青年基金(22012524)
关键词
产前诊断
羊水细胞培养
染色体核型分析
Prenatal diagnosis
Amniotic cell culture
Chromosome karyotyping
