摘要
DNA损伤是细胞最常见的损伤，DNA修复蛋白可以对DNA损伤进行修复，在维持生物体基因组的完整性和抑制肿瘤的发生中起着重要的作用。DNA损伤修复基因表达的正常与否与肿瘤的进展有关。该文对目前的研究热点——人类X射线交叉互补修复基因（XRCC）家族中XRCCl、XRCC2和Rad51基因多态性与肿瘤的关系进行了综述。
DNA repair protein can repair DNA damage of cells and play important roles in maintaining the integrity of the genetic information and suppressing the formation of tumor. The expression of DNA repair genes associates with the development of tumors. In this review, an overview of the relationship between XRCC 1, XRCC2 and Rad51 polymorphism of X-ray repair cross complementing gene family and tumors was introduced.
出处
《国际放射医学核医学杂志》
2013年第6期370-373,共4页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（30870583）
关键词
DNA修复
多态性
单核苷酸
肿瘤
X射线交叉互补修复基因
DNA repair
Polymorphism, single nucleotide
Neoplasms
X-ray repair cross comple-menting gene
