摘要
目的：探讨急性白血病（AL）患者骨髓微小残留病（MRD）的监测对疾病预后和疗效评价的临床意义．方法对2009年1月2012年12月在玉溪市人民医院血液科正规治疗的43例急性白血病患者采用骨髓液，利用流式细胞术（FCM）进行MRD检测，从首次诱导缓解治疗结束后第14天开始，每1～3月检测1次，并动态监测，分为阴性（MRD〈10-4）、阳性（MRD〉10-4），2组进行比较分析．结果阴性、阳性2组3 a的复发率分别为0、80%，2组复发率的差异有统计学意义（＜0.05）．而在形态学完全缓解时，MRD阳性组复发率明显高于阴性组（＜0.05）．结论采用FCM检测AL患者的MRD，MRD〉10-4患者复发率高于MRD〈10-4患者，MRD阳性比传统骨髓形态学复发出现早，连续对完全缓解AL患者进行MRD监测对指导治疗及早期预测复发具有重要的临床意义．
Objective Investigate the clinical significance of bone marrow minimal residual disease （MRD） detection to prognosis and therapeutic evaluation in acute leukemia （AL） after complete remission （CR）. Methods Forty-three cases of bone marrow specimens in patients with acute leukemia were collected from 209-2012. The MRD was detected using multiparameter flow cytometry （FCM）. The detection was performed from the beginning of induction chemotherapy by CR, and detected at 1, 3, 6 and 12 months. According to the CR detection for the first time, the induced MRD levels were obtained after treatment, then 43 patients with AL were divided into negative （MRD 〈 104） and positive （MRD〉10-4） two groups. Results The recurrence rate after three years of the two groups was 0 and 80%, respectively. There was a significant difference in the recurrence rate （P 〈 0.05） . The recurrence rate of positive group was significant higher than that of negative group （P 〈 0.05） when the morphologic of MRD was complete remission. Conclusion Using FCM to detect AL MRD, MRD 〉 10-4 AL-CR have the high recurrence rate, and the recurrence of positive group have appeared early than traditional MRD bone marrow morphology. The continuous MRD detection of AL-CR has important clinical significance in the prognosis and early prediction for recurrence
出处
《昆明医科大学学报》
CAS
2013年第11期108-110,共3页
Journal of Kunming Medical University
关键词
白血病
微小残留病
意义
Leukemia
Minimal residual disease
Significance
