摘要
目的探讨脑卒中后抑郁(PSD)对脑卒中患者认知功能的影响和相关性;评价认知电位P300在PSD认知功能诊断中的应用价值.方法连续观察神经内科住院的急性脑卒中患者117例,发病第2周时给予HAMD量表评分;对53例PSD及64例NPSD(脑卒中后非抑郁)患者分别进行MMSE评分及P300测定,并将结果进行比较.结果脑卒中后2周PSD的发生率为45.29%(53/117),其中轻度抑郁35例(29.91%);中度抑郁11例(9.40%);重度抑郁7例(5.98%).PSD组与NPSD组相比,P300潜伏期显著延长(P<0.01),且波幅显著降低(P<0.01);两者MMSE评分差异有统计学意义(P<0.05).结论 PSD以轻中度抑郁为主,PSD患者的认知功能损害较NPSD明显,P300测定可作为PSD患者认知功能诊断的评定指标.
Objective To investigate the influence of the post stroke depression （PSD） on cognitive function in patients with stroke and their correlation, and to evaluate the diagnosis value of P300 cognitive function in patients with PSD. Methods One hundred and seventeen cases of inpatient with acute stroke in neurology medicine were continuously observed and scored using HAMD rating scale at the onset of 2 weeks. And 53 cases of PSD and 64 cases of non-post-stroke depression （NPSD） were scored using MMSE score and P300 determination respectively,and the results were compared. Results The incidence of PSD was 45.29%（53/117） at the 2 weeks after stroke,including 35 cases （29.91%） of mild depression,11 cases （9.40%） of medium degree depression and 7 cases （5.98%） of major depression. Compared with NPSD group, the P300 latency period of PSD group was significantly prolonged （ 〈 0.01）, and the amplitude significantly reduced （ 〈 0.01） . The MMSE score difference was statistically significant （ 〈0.05） in the two groups. Conclusion The PSD is given priority to with mild-to-moderate depression, and the cognitive function damage in patients with PSD is more obvious than that in NPSD group. P300 determination can be used as the evaluation indicator of diagnosis cognitive function in patients with PSD.
出处
《昆明医科大学学报》
CAS
2013年第11期37-39,共3页
Journal of Kunming Medical University
基金
云南省教育厅科学研究基金资助项目(2010C107)
关键词
脑卒中后抑郁
认知功能
认知电位P300
Post stroke depression
Cognitive function
Cognitive potential- P300
