摘要
目的评估IL-17Frs763780多态性与癌易感性的关联。方法通过检索Pubmed、Embase、OV-ID、CBM、WanfangData和CNKI，筛选出发表至2013年10月与IL-17基因多态性和癌易感性有关的病例对照研究。采用比值比（ORs）和95％可信区间（95％CIs）评价关联强度。结果最终纳入5篇病例对照研究，包括1407例肿瘤患者和2164例健康对照。然而，分析后发现IL-17Frs763780多态性和癌无统计学意义的关联（TT＋TC vs CC：OR=0．85，95％CI=0．46～1．57，P=0．60；TTVSTC＋CC：OR=1．00，95％CI=0．76-1．33，P=0．99；TC vs CC：OR=0．83，95％CI=0．44—1．55，P=0．55；TT vs CC：OR=0．85，95％CI=0．46-1．59，P=0．62）。按肿瘤类型亚组分析提示在胃癌和其他肿瘤存在相似的结果。结论IL-17Frs763780多态性可能并不增加肿瘤的易感性。
Objective To examine the relationship between IL-17F rs763780 polymorphism and cancer risk. Methods Pubmed, Embase, OVID, CBM, Wanfang Data and CNKI were searched for case-control studies published up to October 2013 which investigated IL-17 gene polymorphism and cancer susceptibility. Odds ratios （ORs） with 95 % confidence intervals （95% CIs） were used to estimate the strength of association. Results Five studies were included, involving a total of 1407 cancer cases and 2164 healthy controls. No statistical relationship was observed between IL-17F rs763780 variant and cancer risk （TIP ＋ TC vs. CC： OR =0. 85, 95% CI =0. 46 - 1.57, P = 0.60; Trvs. TC ＋ CC： OR=1. 00, 95% CI=0.76 - 1.33, P=0.99; TC vs. CC： OR= 0.83, 95% CI=0.44 - 1.55, P=0.55; Trvs. CC： OR=0.85, 95% CI=0.46 - 1.59, P = 0. 62） . In terms of cancer type, the subgroup analysis revealed similar results in gastric cancer and other cancers. Conclusions The IL-17F rs763780 polymorphism fails to increase the suscepti- bility to cancer.
出处
《医学分子生物学杂志》
CAS
2013年第6期340-343,共4页
Journal of Medical Molecular Biology
