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青光眼暗室激发试验的眼前节相关因素分析

The correlative factors of darkroom provocative test in anterior segment parameters
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摘要 目的 分析房角狭窄患者暗室激发试验阳性者的相关眼前节结构参数.方法 回顾性系列病例研究.分析260例房角狭窄患者的暗室试验结果和超声生物显微镜(UBM)眼前节结构参数.其中男性36例,女性224例,平均年龄(59.6±9.3)岁.眼前节结构参数包括前房深度(ACD)、瞳孔直径(PD)、晶状体矢高(LV)、周边虹膜厚度(IT)、虹膜膨隆度(IC)、房角开放距离(AOD)、小梁网睫状突夹角(TCPA)及房角接触性关闭的象限数(NPAC).用单因素和多因素Logistic回归分析青光眼暗室激发试验阳性的相关因素.结果 260例房角狭窄者青光眼暗室激发试验的阳性率为27.3% (71/206),男性阳性率(41.7%,15/36)大于女性(25.0%,56/224),差异有统计学意义(x2=4.340,P=0.037).单因素分析表明,男性(OR =2.14)、AOD(OR=0.98)、IT(OR=1.68)、NPAC(OR=2.24)是暗室试验阳性的相关因素;多因素Logistic回归分析表明,IT(OR=1.47)、NPAC(OR=1.70)是暗室试验阳性的独立相关因素.结论 房角和虹膜参数与房角狭窄者的青光眼暗室激发试验阳性结果相关,IT和NPAC是暗室激发试验阳性的独立相关因素. Objective To investigate the correlative anterior segment parameters of positive darkroom provocative test in patients with narrow anterior chamber angles.Methods It was a retrospective case series study.Two hundred and sixty patients [36 males and 224 females,mean age (59.6 ± 9.3) years] with narrow anterior chamber angles underwent darkroom provocative test and UBM scan were analyzed retrospectively.Anterior segment parameters including anterior chamber depth (ACD),pupil diameter (PD),lens vault (LV),peripheral iris thickness (IT),iris convex (IC),anterior chamber angle open distance (AOD),trabecular-meshwork ciliary process angle (TCPA) and the number of appositional angle closure (NPAC) were quantitatively analyzed.Correlative factors of positive results were analysis by both single factor and multiple-factor analysis.Results Seventy-one (27.3%) of the 260 patients had positive results in the darkroom provocative test.Males(15 out of 36)had statistically higher positive result rate than females (56 out of 224) (M:41.7% vs.F:25.0%,x2 =4.340,P =0.037).In single factor analysis,male (OR =2.14),AOD (OR =0.98),IT (OR =1.68) and NPAC (OR =2.24) were correlative factors for positive results.In multiple-factor analysis,only IT (OR =1.47) and NPAC (OR =1.70) were independent risk factors of positive results.Conclusions Positive darkroom provocative test is correlated to parameters of anterior chamber angle and iris,while IT and NPAC are independent correlative factors in patients with narrow anterior chamber angle.
出处 《中华眼科杂志》 CAS CSCD 北大核心 2013年第11期968-972,共5页 Chinese Journal of Ophthalmology
基金 广东省自然科学基金(S2011010006046)
关键词 暗适应 显微镜检查 声学 眼前半段 眼内压 青光眼 闭角型 Dark adaptation Microscopy, acoustic Anterior eye segment Intraocular pressure Glaucoma, angle-closure
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