摘要
目的 探索大肠恶性肿瘤血液流变学及血脂水平变化的规律 ,评价其临床意义。方法 对 64例大肠恶性肿瘤、2 6例大肠息肉、3 6例普通病人检测了血液流变学指标、血甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白。结果 大肠息肉组与正常组各项指标间无明显差异 ,大肠癌有淋巴结转移及远处转移时全血中、低切粘度、血浆粘度、全血还原粘度、红细胞聚集指数、红细胞变形指数、血沉方程K值均明显增高 ,血甘油三酯、低密度脂蛋白及极低密度脂蛋白也增高。结论 随着大肠癌病情的发展 ,血脂代谢出现异常 ,血液流变学出现明显变化 ,动态观察血液流变学和血脂改变 ,对大肠癌诊治及监测有重要意义。
Objective The change of hemorheological parameters and lipid metabolism in patients with large bowel malignancies was studied to explore their clinical value.Method 64 cases of colorectal cancer,26 cases of colorectal polyps and 36 control cases were given an examination of their hemorheological parameters and the level of triacylglycerol,cholesterol,VLDL,LDL,HDL in the blood.Results There was no significant differece in each index between polyps group and control group.When lymph node metastasis and far metastasis occurred,we found a significant elevation in whole blood low-shear and medium-shear viscosity,plasma viscosity,reductive viscosity of whole blood,aggregation and deformability index of red cell,equation K value of erythrocyte sedimentation,triacylglycerol,VLDL and LDL.Conclusion There are abnormal lipid metabolism and obvious change of hemorheology accompaning large bowel malignancies development.Dynamic observation plays an important role in cancer diagnosis,therapy and montioring.
出处
《河南肿瘤学杂志》
2000年第6期405-406,共2页
Henan Journal of Oncology
关键词
大肠癌
血液流变学
血脂
代谢
large bowel maligancy
hemorheololgy
lipid
