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右旋美托咪啶联合丙泊酚不同靶控浓度下双腔管全麻诱导比较

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摘要 目的研究右旋美托咪啶联合丙泊酚不同靶控浓度下双腔管全麻诱导的观察和对照。方法单肺通气全麻胸外科手术患者45例,随机分成A、B、C三组,予0.5μg·kg-1剂量右旋美托咪定泵注后,分别予1μg·ml-1、2μg·ml-1、3μg·ml-1靶控浓度的丙泊酚靶控诱导,5 min后插管,分别记录入室时基础值(T0)、泵注右旋美托咪啶后(T1)、插管前(T2)、插管时(T3),就位后1 min(T4)、3 min(T5)、5 min(T6)的MAP、HR及BIS值。结果组内与基础值比较1μg·ml-1组插管时和就位后1 min、3 min均明显升高(*P<0.05),3μg·ml-1组插管前和就位后3 min、5 min均降低(*P<0.05);与2μg·ml-1组比较,1μg·ml-1组插管时和就位后1 min明显增高(#P<0.05),3μg·ml-1组插管前和就位后5 min较低(#P<0.05)。结论本研究可见2μg·ml-1靶控浓度的丙泊酚复合右旋美托咪啶的麻醉诱导方案组,插管前后血压、心率及BIS值与另外两组同时间点的指标有显著性的统计学意义(P<0.05),说明了右旋美托咪啶辅助麻醉诱导下,丙泊酚2μg·ml-1靶控浓度即可以充分的抑制了双腔管插管就位时气道的强烈应激,同时避免了插管前、就位后的深麻醉所致的循环过度抑制,保证了整个麻醉诱导期的循环稳定。总之,2μg·ml-1的靶控浓度可以说是右旋美托咪啶辅助下丙泊酚靶控双腔管全麻麻醉诱导相对理想的靶控浓度。
出处 《齐齐哈尔医学院学报》 2013年第20期3027-3028,共2页 Journal of Qiqihar Medical University
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