摘要
目的探讨盐酸莫西沙星氯化钠注射液治疗不同降糖药物控制的老年2型糖尿病合并肺部感染的临床疗效。方法将62例2型糖尿病合并肺部感染患者按治疗方法的不同分为2组:治疗组(胰岛素治疗组,38例)和对照组(口服降糖药对照组,24例)。2组患者均采用常规、对症治疗。在此基础上,治疗组患者采用盐酸莫西沙星氯化钠注射液治疗。同时,采用精蛋白锌重组赖脯胰岛素混合注射液(50R)治疗。对照组患者采用格列喹酮片联合阿卡波糖片治疗。观察2组患者治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(2 h PG)]的变化及临床疗效的情况。结果治疗组治疗后FBG、2 h PG水平均明显低于对照组[(8.56±1.20)、(6.60±2.20)mmol·L-1比(10.37±1.60)、(7.95±1.60)mmol·L-1,均P<0.05],治疗组治愈率、总有效率均明显高于对照组(68.4%、94.7%比41.7%、75.0%,均P<0.05)。结论老年2型糖尿病合并肺部感染胰岛素控制血糖的患者抗生素治疗疗效优于口服降糖药控制血糖的患者,且胰岛素降血糖更适合于老年2型糖尿病,也利于合并肺部感染的抗生素治疗。
Objective To explore the curative efficacy of moxifloxacin hydrochloride and sodium chloride injection in elderly patients with type 2 diabetes mellitus and lung infection controlled by different hypoglycemic agents.Methods Sixty-two patients with type 2 diabetes mellitus and lung infection were divided into two groups according to different therapy：insulin treatment group （treatment group,n=38） and oral hypoglycemic agents （control group,n=24）.The patients of two groups were given conventional and symptomatic treatment.In treatment group,moxifloxacin hydrochloride and sodium chloride injection and mixed protamine zinc recombinant human insulin lispro injection （50R） were given. In control group,gliquidone tablets and acarbose tablets were given.Fasting blood glucose（FBG）, 2-hour postprandial blood glucose （2-hour PG） and clinical efficacy were observed before and after treatment in both groups.Results The levels of FBG and 2-hour PG in treatment group were signif- icantly lower than those in control group after treatment [（8.56±1.20） and （6.60±2.20） mmol-L-lvs （ 10.37±1.60） and （7.95± 1.60） mmol L-1, respectively; P〈0.05].However, the cure rate and total effective rate in treatment group were significantly higher than those in the control group （68.4% and 94.7% vs 41.7% and 75.0% ,respectively;P〈0.05）. Conclusion Antibiotics may have better effect than oral hypoglycemic agents in elderly patients with type 2 diabetes mellitus and lung infection. Insulin is moresuitable for blood glucose control and is conducive to antibiotic treatment of pulmonary infection in elderly patients with type 2 diabetes mellitus.
出处
《实用临床医学（江西）》
CAS
2013年第9期12-14,共3页
Practical Clinical Medicine
关键词
糖尿病
2型
肺部感染
莫西沙星
格列喹酮
阿卡波糖
老年人
diabetes mellitus,type 2
lung infect.ion
moxifloxacin
gliquidone tablets
acarbose tablets
elderly
