摘要
[目的]探讨孕期暴露1800MHz电磁波对子代大鼠海马细胞凋亡的影响。[方法]以7周龄无特定病原体（SPF）级SD大鼠24只（雌鼠16只、雄鼠8只），雌雄2：1合笼。孕鼠随机分为0．5mW／cm^2暴露组、对照1组；1．0mW／cm^2暴露组、对照2组；暴露组采用1800MHz射频电磁波对大鼠于孕第0～20天进行连续21d全身暴露，每天12h，功率密度分别为0．5mW／cm^2和1．0mW／cm^2。各组于出生后第3周和第7周时，分别随机抽取8只仔鼠（雌雄各半）测定其海马细胞凋亡率。[结果]孕期暴露于密度为1800MHz0．5mW／cm^2的电磁波，3周龄仔鼠海马细胞凋亡率显著高于两对照组和1．0mW／cm^2暴露组（P〈0．05），1．0mW／cm^2暴露组海马细胞凋亡率与两个对照组相比，差异无统计学意义（P〉0．05）；7周龄仔鼠海马细胞凋亡率，0．5mW／cm^2和1．0mW／cm^2组均高于两个对照组（P〈0．05），两个对照组相比差异无统计学意义（P〉0．05）。[结论]大鼠孕期暴露于1800MHz功率密度为0．5mW／cm^2和1．0mW／cm^2的电磁波可致发育期和成年期子代大鼠海马细胞凋亡率升高。
[ Objective ] To study the effects of prenatal exposure to 1 800 MHz electromagnetic waves （EMWs） on apoptosis in hippocampus of offspring rats. [ Mothods ] Twenty-four SPF graded SD rats （male-female ratio, 1 ： 2） at age of 7 weeks old were randomly divided into paired groups ： EMWs exposure group at 0.5 mW/cm2 and paired with control 1 group; EMWs exposure group at 1.OmW/cm2 and paired with control 2 group. The pregnant rats in the exposure groups were respectively and continuously irradiated with 1 800MHz EMWs at a power density of 0.5 mW/cm2 or 1.0mW/cm2 for 12hours per day from day 0 to day 20 of pregnancy. Then 8 offspring rats （male-female ratio, 1 ： 1） were selected from each group at 3 and 7 weeks of age respectively to detect apoptosis rate in hippocampus. [ Results ] The prenatal exposure to 0.5 mW/cm2 EMWs obviously increased apoptosis in hippocampus in the offspring rats at 3 weeks of age compared with the control groups and the 1.0 mW/cm2 group （P 〈 0.05）. The prenatal exposure to 0.5 mW/cm2 and 1.0 mW/cm2 EMWs remarkably increased apoptosis in hippocampus in the offspring rats at 7 weeks of age （P〈 0.05）. [ Conclusion ] Prenatal exposure to 1 800 MHz electromagnetic waves at power density of 0.5 mW/cm2 and 1.0 mW/cm2 may increase apoptosis in hippocampus in young and adult offspring rats.
出处
《环境与职业医学》
CAS
北大核心
2013年第11期818-820,824,共4页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金资助项目(编号:30771773)
关键词
电磁波
海马
细胞凋亡
大鼠
electromagnetic waves
hippocampus
apoptosis
rats
