摘要
目的对比不同药物治疗方案对全面改善大学生首发精神分裂症认知障碍的近期及远期疗效。方法按就诊时间先后选择2008-2012年间我市7所各级精神病院收治的高校在读期间首次发病的精神分裂症患者158例作为研究对象,根据医生选择的药物治疗方案不同分为第一代抗精神病药物组(FGA)56例和第二代抗精神病药物组(SGA)102例,治疗初、治疗1、3、6月时使用中文版精神分裂症认知功能评定量表(SCoRS)对患者认知功能进行全面评定并进行组间组内比较。结果与治疗初比较FGA组、SGA组各阶段SCoRS各因子发生明显改善:神经认知:FGA(t=5.71,13.84,34.08;P<0.01),SGA(t=22.52,55.43,125.91;P<0.01);社会认知:FGA(t=1.66,P<0.05;17.62,39.16;P<0.01),SGA(t=11.44,58.43,96.08;P<0.01);日常生活状态认知:FGA(t=5.65,22.39,55.21;P<0.01),SGA(t=37.63,116.42,187.98;P<0.01)。FGA和SGA组治疗各阶段在认知各方面改善程度上存在明显差异:神经认知(t=12.71,27.28,48.61;P<0.01);社会认知(t=6.15,30.48,42.99;P<0.01);日常生活状态认知(t=18.46,49.87,73.30;P<0.01)。结论抗精神病药能全面改善大学生首发精神分裂症的认知障碍;第二代药物改善程度明显优于第一代药物,远期改善更突出。
Objective To compare the recent and forward curative effect of fully improving cognitive impairment of university students with first-episode schizophrenia by different drug. Methods To choice 158 university students with schizophrenia who cured for first-episode in seven mental hospitals in Tangshan city during universities reading according to the time order from 2008 to 2012..To divide into FGA and SGA groups according to the doctors different drug treatments. To evaluate and contrast cognitive impairment by SCoRS at the beginning of the treatment, 1,3,6 months. Results Each factor of SCoRS in two groups appeared significant improvement at each stage compared with early treatment ： Neurocognitive ： FGA （ t = 5.71,13.84,34.08 ; P 〈 0.01 ）, SGA （ t = 22. 52,55.43,125.91 ; P 〈 0.01 ） ; Social cognition ： FGA （ t = 1.66, P 〉 0. 05 ; 17.62,39. 16 ; P 〈 0.01 ）, SGA （ t = 11.44,58.43,96. 08 ; P 〈 0.01 ） ; Daily life state：FGA（t =5.65,22. 39,55.21 ;P 〈0.01 ） ,SGA（t =37.63,116. 42,187.98 ;P 〈0.01 ）. There were significant differences between two groups on the degree of cognitive impairment at each stage. Neurocognitive （ t = 12.71,27.28,48. 61 ; P 〈 0.01 ） ; Social cognition （ t = 6. 15,30. 48,42. 99 ; P 〈 0. 01 ） ; Daily life state （ t = 18.46,49. 87,73.30 ; P 〈 0. 01 ）. Conclusion Antipsychotic drugs can fully improve university students＇ cognitive impairment with first-episode schizophrenia;SGA is much better than FGA especially in the forward.
出处
《中国健康心理学杂志》
2013年第11期1624-1626,共3页
China Journal of Health Psychology
