摘要
目的研究肌电生物反馈联合早期康复对急性脑梗死患者临床疗效和血清基质金属蛋白酶-9(MMP-9)水平的影响。方法90例急性脑梗死偏瘫患者,采用随机数字表法分为对照组(n=30)、康复组(n=30)和综合组(n=30)。所有患者均接受常规药物治疗,康复组采用早期康复,综合组采用肌电生物反馈联合早期康复,治疗2周。于治疗前后采用临床神经功能缺损评分(CNFDS)及改良Barthel指数(MBI)进行评定,检测血清MMP-9水平。结果治疗后,各组CNFDS评分显著下降,MBI评分显著升高(P<0.001),综合组明显优于康复组、对照组(P<0.01)。各组血清MMP-9水平下降,综合组下降更明显(P<0.001)。结论肌电生物反馈联合早期康复可促进神经功能的恢复,机制可能与降低血清MMP-9水平有关。
Objective To observe the effect of electromyographic biofeedback combined with earlier rehabilitation on serum matrix me-talloproteinase-9 （MMP-9） and its clinical efficacy for patients with cerebral infarction. Methods 90 patients with acute cerebral infarction were randomly divided into control group （n=30）, rehabilitation group （n=30） and combination group （n=30）. All the groups received basic medication, and the rehabilitation group combined with earlier rehabilitation, the combination group with electromyographic biofeedback and earlier rehabilitation. All patients were evaluated with Clinical Neurologic Functional Default Scoring （CNFDS） and the modified Barth-el Index （MBI） before and 2 weeks after treatment. Their serum levels of MMP-9 were detected as well. Results The scores of CNFDS and MBI improved after treatment in all the groups （P〈0.001）, especially in the combination group （P〈0.01）. The levels of MMP-9 decreased more in combination group than in the rehabilitation group and the control group （P〈0.001）. Conclusion Electromyographic biofeedback combined with earlier rehabilitation can facilitate the recovery neural function, which may associated with the decrease of MMP-9.
出处
《中国康复理论与实践》
CSCD
北大核心
2013年第11期1043-1045,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
山西省高校科技研究开发项目(No.20121014)
关键词
脑梗死
肌电生物反馈
早期康复
基质金属蛋白酶-9
cerebral infarction
electromyogmphic biofeedback
earlier rehabilitation
matrix metalloproteinase-9
