摘要
目的:研究消化内镜合并四联疗法治疗胃溃疡出血的临床疗效及再出血因素.方法:选取我院2010-02/2012-02胃溃疡出血患者164例,随机分为治疗组及对照组各82例,治疗组应用消化内镜治疗联合四联疗法,对照组单用四联疗法进行治疗,对比疗效并分析其预后的影响因素.结果:治疗组有效率为96.2%,164例患者中,39例(23.8%)患者发生再次出血(A组),135例(82.3%)患者未发生再次出血(B组).其中治疗组出血13例(15.8%),对照组出血26例(31.7%).A组出血量、溃疡A1期人数百分比均大于B组,血红蛋白、血小板、是否内镜治疗人数百分比均小于B组.多因素分析表明溃疡A1期人数百分比、血红蛋白及是否内镜治疗人数百分比均为独立危险因素.结论:消化内镜联合四联疗法治疗胃溃疡出血效果好,未用内镜治疗,血红蛋白低,溃疡A1期为再出血的危险因素.
AIM： To assess the clinical efficacy of endoscopy combined with quadruple therapy in the treat- ment of gastric ulcer bleeding. METHODS： One hundred and sixty-four pa- tients with gastric ulcer bleeding treated at our hospital from February 2010 to February 2012 were randomly divided into either a treatment group or a control group, with 82 cases in each group. The treatment group underwent endo- scopic therapy combined with quadruple thera- py, while the control group received quadruple therapy only. The efficacy and factors associated with re-bleeding were analyzed. RESULTS： The response rate was 96.2% in the treatment group. Of all 164 patients, 23.8% developed re-bleeding. The amount of bleeding and the percentage of patients with Phase A1 or more ulcer were higher in the control group than in the treatment group. Hemoglobin, platelet count, and the percentage of patients undergo- ing endoscopic treatment were less in the control group than in the treatment group. Multivariate analysis showed that ulcer grade, hemoglobin and endoscopic treatment were independent risk factors for re-bleeding. CONCLUSION： Digestive endoscopy combined with quadruple therapy is safe and effective in the treatment of gastric ulcer bleeding. Endo- scopic treatment, lower hemoglobin, and higher ulcer grade are risk factors for re-bleeding.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第31期3409-3412,共4页
World Chinese Journal of Digestology
关键词
消化内镜
四联疗法
胃溃疡
临床疗效
预
后分析
Digestive endoscopy
Quadruple thera-py
Gastric ulcer
Rehaemorrhagia
Clinical efficacy
