摘要
目的运用循证医学方法为1例黏液型铜绿假单胞菌感染的患者制定抗感染治疗方案。方法根据患者的具体情况,提出所需解决的临床问题,全面检索Cochrane图书馆、PubMed数据库、中国期刊全文数据库和万方数据库,查找大环内酯类药物应用于黏液型铜绿假单胞菌感染的相关系统评价、Meta分析、临床随机对照试验,并对所获证据进行质量评价,进而将最佳证据应用于临床实践。结果低浓度阿奇霉素与抗铜绿假单胞菌抗菌药物联用可清除曾经受到生物膜保护的致病菌。将以上证据提供给临床并结合患者及家属意愿后应用效果良好。结论应用循证医学的方法可以为临床提供充分的证据,帮助临床决策,为患者制定合理的治疗方案,提高患者治疗效果。
OBJECTIVE To formulate an evidence-based treatment plan for a patient with bronchiectasis infected the mucoid Pseudomonas aeruginosa. METHODS A search was conducted in the Cochrane Library, PubMed, CNK1 and Wanfang Data to obtain and evaluate the relevant systematic reviews, meta-analysis and randomized controlled and finally to apply the best evidence in clinical practice. RESULTS The pathogens once protected by the biofilm could be cleared by the low dose of azithromycin associated with anti-Pseudomonas aeruginosa antimicrobial agents. The results was good after the the plan was applied to the patient. CONCLUSION To formulate an evidence-based treament plan can improve the patient curative effect.
出处
《中国现代应用药学》
CAS
CSCD
2013年第11期1236-1239,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
铜绿假单胞菌
生物被膜
大环内酯
阿奇霉素
循证治疗
支气管扩张
Pseudomonas aeruginosa
biofilm
macrocyclic lactone
azithromycin
evidence-based treatment
bronchiectasis
