摘要
目的分析广东珠海地区幽门螺杆菌(Hp)临床分离株体外多重耐药特点,为临床根除Hp治疗提供依据。方法对珠海地区312例经胃镜确诊、活检快速尿素酶试验阳性的慢性胃炎患者行Hp分离及菌株培养,采用折点敏感试验方法测定Hp对甲硝唑、呋喃唑酮、阿莫西林、克拉霉素的单药及多药耐药情况。结果共获得95株Hp菌株,其对4种抗生素耐药率由高到低依次为甲硝唑、呋喃唑酮、阿莫西林、克拉霉素,双重耐药率为30.53%～58.95%,多重耐药率26.32%～37.89%。结论广东珠海地区Hp多重耐药情况严重,行根除Hp治疗时应尽量避免应用甲硝唑;应进行药敏试验,寻求个体化治疗方案。
Objective To analyze the prevalence of multidrug-resistant Helicobacter pylori （Hp） in patients with chronic gastritis in Zhuhai and to provide basis for the medication for Hp eradication. Methods A total of 312 patients with chronic gastritis diagnosed by gastroscopy and with positive biopsies tested by rapid urease underwent Hp separation and then the bacterial strains were cultured in fluid nutrient medium. The drug resistance or multidrug-resistance of Hp to metronidazole, furazolidone, amoxicillin and clarithromycin was detected by breakpoint sensitive test. Results Ninety- five Hp strains were cultured. The resistance rates against the evaluated agents from the highest to the lowest were metron- idazole, furazolidone, amoxicillin and clarithromycin. Dual resistance rates against the evaluated agents were between 30.53% and 58.95%, and multidrug-resistance rates were between 26.32% and 37.89%. Conclusions The multi- drug-resistance of Hp in Zhuhai is serious. As for the Hp eradication therapy, we should avoid using metronidazole, per- form susceptibility testing and seek individualized treatment plan.
出处
《山东医药》
CAS
2013年第42期23-25,共3页
Shandong Medical Journal
基金
广东省珠海市科技工贸和信息化局项目(2011B040102006)
关键词
幽门螺杆菌
感染
抗生素
耐药
Helicobacter pylori, infections
antibiotics, drug resistance
