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原发性高血压伴发非酒精性脂肪性肝病的多代谢异常 被引量:5

Cross-sectional study of multiple metabolic disorders in patients with essential hypertension and nonalcoholic fatty liver disease
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摘要 目的 探讨原发性高血压(EH)患者伴发非酒精性脂肪性肝病(NAFLD)的患病率和多代谢异常的关系.方法 横断面调查.对2006年1月至2008年7月期间在北京安贞医院住院的诊断为EH的1109例患者住院期间采集病史和经腹部超声检查筛查NAFLD,观察其NAFLD患病率、血清丙氨酸转氨酶异常的比例及其与血糖、血脂异常、高尿酸血症等多代谢异常的关系,平均(61±11)岁;男567例,女542例.相同时期住院的471例非EH者作为对照组,平均(62±10)岁;男255例,女216例.组间比较计量资料用t检验,计数资料采用X2检验.采用Logistic多元回归法分析EH伴发NAFLD的危险因素.结果 EH患者伴发NAFLD患者发生率为37.3% (414/1109).EH患者分为NAFLD组和非NAFLD组.NAFLD组糖尿病(21.0%∶10.8%),BMI(26.90±3.66∶26.35 ±3.56),超重率(71.3%∶62.9%),代谢综合征发生率(59.4%∶44.7%),血清总胆固醇(5.30±1.17∶5.12±1.09),三酰甘油(2.11±1.43∶1.85±1.33),ALT (45.18±37.62∶39.22±32.27)高于非NAFLD组,HDL-C(1.53±0.53∶1.62±0.54)低于非NAFLD组,差异有统计学意义(P均<0.05).非NAFLD组的EH患者BMI,超重率,UA,TG,ALT均高于非EH组,差异有统计学意义(P均<0.01).多因素Logistic回归分析中,糖尿病、总胆固醇、血尿酸水平、BMI是EH患者NAFLD的独立危险因素.结论 EH伴NAFLD患者与血脂、血尿酸等多代谢异常密切相关. Objective To investigate the incidence of non-alcoholic fatty liver disease (NAFLD) in essential hypertension patients and the relation between NAFLD and multiple metabolic disorders. Methods Cross-sectional study. Between January 2006 and July 2008, 1109 inpatients in Beijing Anzhen hospital diagnosed with essential hypertension were enrolled into this study(542 femal,567 male, mean age 61 ± 11 ). All patients had ultrasound screening for fatty liver. The prevalence of NAFLD, serum alanine aminotransferase abnormality ratio, the relationship between NAFLD and multiple metabolic abnormalitiesincluding glucose, dyslipidemia, hyperuricemia. 471 cases of non-EH as a control group in the same period of admission(216 femal,255 male,mean age 62 ± 10). The measurement data of two groups were compared with t test,while the count data were compared with x^2 test. Multiple Logistic regression was used to analysis therisk factors of EH with NAFLD. Results Among 1109 recruited patients, 37.3% (414/1109) had fatty liver by ultrasonography. EH patients were divided into NAFLD group and non-NAFLD group. In EH co- existed with NAFLD group, the prevalence of diabetes mellitus (21.0% : 10. 8% ), metabolic syndrome (59.4% : 44. 7% ), overweight ( 71.3% : 62. 9% ) and the levels of BMI ( 26. 90 ± 3.66: 26. 35 ± 3.56 ), TC (5.30±1.17: 5. 12 ± 1.09),TG(2. 11 ± 1.43:1.85 ± 1.33) ,ALT(45. 18 ±37.62:39.22 ±32.27) were significantly higher than those in the non-NAFLD group (P 〈 0. 05). HDL-C ( 1.53 ± 0. 53 : 1.62 ± 0. 54) was significantly lower than that in the non-NAFLD group ( P 〈 0. 05 ). In non-NAFLD group, prevalence of overweight and the levels of BMI, TC, TG, ALT were significantly higher than those in non-EH group ( P 〈 0. 01 ). By muhivariable logistic regression analysis, diabetes mellitus, hypercholesteremia, hyperuricemia and BMI were risk factors in NAFLD patients with essential hypertension. Conclusion NAFLD was more prevalent in p
作者 李庆祥 袁慧
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2013年第10期926-930,共5页 Chinese Journal of Laboratory Medicine
关键词 高血压 脂肪肝 代谢疾病 Hypertension Fatty liver Metabolic diseases
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