摘要
目的 研究c met蛋白在胃粘膜病变演进过程中的表达及关系 ,探讨c met表达对胃癌预后的意义。方法 对 16 9例经病理证实的不同胃粘膜病变采用免疫组织化学SP法检测c met蛋白表达 ,用Kaplan Meier法的Log rank检验胃癌生存率。结果 在浅表性胃炎、萎缩性胃炎、肠化生、异型增生、早期胃癌和进展期胃癌中 ,c met蛋白表达率分别为 2 3 .5 % (4 17) ,36 .8% (14 38) ,5 1.5 %(17 33) ,6 1.3% (19 31) ,6 6 .7% (8 12 )和 73.7% (2 8 38) ,而且肠化生、异型增生、胃癌均显著高于浅表性胃炎 (P <0 .0 5 )。胃粘膜增殖程度与c met阳性表达强度密切关系分析 ,两者有显著关联 (P <0 0 1)。c met阳性表达与胃癌组织类型、浆膜浸润和淋巴结转移密切相关 ,而且BorrmannⅣ型明显高于早期胃癌和BorrmannⅠ、Ⅱ型 (P <0 .0 1)。c met阳性表达胃癌患者生存率显著差于阴性表达者。结论 c met蛋白表达与胃粘膜增殖和恶化有关。c met蛋白可能成为评估胃癌预后的一项新的重要指标。
Objective To determine whether there is a relationship between the expression of c-met oncogene and the stage of gastric mucosal lesions or the prognosis of gastric carcinomas. Methods Expression of c-met was investigated in 169 gastric mucosal lesions by using immunohistochemistry. Survival analysis was studied with the Kaplan-Meier test. Results For chronic superficial gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia, early gastric carcinomas and advanced gastric carcinomas, the expression rates were 23.5%, 36.8%, 51.5%, 61.3%, 66.7% and 73.7% respectively. The positive rate was higher in intestinal metaplasia, dysplasia and gastric carcinomas than in chronic superficial gastritis ( P <0.05). Expression of c-met increased with the increasing proliferation of gastric mucosa in rank correlation test, which showed a close relationship ( P <0.01). Expression of c-met correlated significantly with histologic type, serosal invasion and lymph node metastases. In particular, the expression of c-met was significantly higher in Borrmann type IV gastric carcinomas (87.5%) than in early gastric carcinomas (66.7%) or Borrmann type I,II (68.7%, P <0.01). The survival rate of patients with expression of c-met was significantly lower than that of patients without c-met expression. Conclusion The expression of c-met is associated with proliferation and malignant transformation of gastric mucosa. These results suggest that expression of c-met might be a new prognostic factor in gastric carcinoma.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2000年第6期409-411,共3页
Chinese Journal of Pathology
