摘要
目的 探讨慢性肾脏病（CKD）患者血清鳞状细胞癌抗原（SCC）和细胞角蛋白19片段抗原21-1（CYFRA21-1）浓度变化及其临床意义.方法 选择90例CKD患者作为CKD组,根据其血清肌酐值再分为高肌酐组（47例,血清肌酐超过93 μmol/L）及正常肌酐组（43例,血清肌酐为39～91 μmol/L）,同期选择42例健康人作为对照.血清SCC、CYFRA21-1及肌酐的检测分别采用化学发光微粒子免疫分析法、电化学发光免疫分析法及苦味酸法.结果 高肌酐组患者血清SCC、CYFRA21-1浓度均明显高于正常肌酐组及对照组（P〈0.05）,正常肌酐组患者血清SCC、CYFRA21-1浓度均明显高于对照组（P〈0.05）.CKD组患者血清肌酐浓度与血清SCC、CYFRA21-1浓度呈正相关（rSCC=0.66,rCYFRA21-1=0.25,P〈0.05）.结论 血清SCC、CYFRA21-1水平可作为判断患者肾功能的指标.
Objective To explore changes of serum squamous cell carcinoma antigen（SCC） and cytokeratin 19 fragment antigen 21-1（CYFRA21-1） concentration of patients with chronic kidney disease（CKD） and their clinical significance. Methods 90 patients with CKD were selected as CKD group, which subdivided into high creatinine group（47 cases with serum creatinine over 93 μmol/ L） and normal creatinine group（43 cases with serum creatinine 39-91 μmol/L） according to their serum creatinine values. 42 healthy people were selected as control simultaneously. Chemiluminescence microparticle immunoassay, eiectrochemiluminescence immunoassay and picric acid method were employed to detect serum SCC,CYFRA21-1 and creatinine,respectively. Results Serum SCC and CYFRA21-1 concentration of patients in high creatinine group were significantly higher than those in the normal creatinine group and the control group（P〈0.05） and those in the normal creatinine group were markedly higher than those in the control group（P〈0.05）. Serum creatinine concentration of patients in CKD group was positively correlated to the serum SCC and CY- FRA21-1 concentration（rSCC=0.66,rCYFRA21-1=0.25,P〈0.05）. Conclusion Serum levels of SCC and CYFRA21-1 could be used as indicators of renal function.
出处
《国际检验医学杂志》
CAS
2013年第21期2814-2815,共2页
International Journal of Laboratory Medicine
基金
上海市科委重点科技攻关项目(11DZ1973100)
上海高校创新团队建设项目
关键词
鳞癌相关抗原
细胞角蛋白
肌酐
肾脏疾病
squamous cell carcinoma antigen
cytokeratin
creatinine
kidney diseases
