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2型糖尿病患者血尿酸、尿微量白蛋白水平与视网膜病变的相关性研究 被引量:5

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摘要 目的探讨2型糖尿病患者尿白蛋白排泄率(UAER)及血尿酸(UA)水平与糖尿病视网膜病变(DR)的关系。方法 443例2型糖尿病患者按照眼底结果分为无DR组(NDR)、非增殖期DR组(NPDR)及增殖期DR组(PDR),观察各组临床生化指标并分析DR病变的危险因素。结果本研究人群中DR的患病率为40.41%(179/443),NPDR的患病率为34.76%(154/443),PDR的患病率为5.64%(25/443)。NPDR组及PDR组患者糖尿病病程、糖化血红蛋白(HbA1c)高于NDR组(<0.05)。PDR组收缩压(SBP)、总胆固醇(TC)及低密度脂蛋白(LDL)高于NDR组(<0.05),血肌酐(Cr)、UA、UAER高于NDR及NPDR组(<0.05),肾小球滤过率(GFR)明显低于NDR及NPDR组(<0.05)。随着UAER的增加,DR发生率明显增加(<0.05)。高尿酸血症组患者DR发生率明显增加(<0.05)。Logistic回归分析显示糖尿病病程、HbA1c、UAER、UA、eGFR为影响DR的独立危险因素。结论 UAER及UA与DR发生密切相关,对其进行联合筛查有助于早期检出DR。
作者 康俏玲 符艳
出处 《现代实用医学》 2013年第10期1150-1151,1162,共3页 Modern Practical Medicine
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