摘要
肾细胞癌通常有对经典放疗或化疗方法仅有轻微的反应和预后差的特点。免疫治疗是在已建立的传统的治疗模式基础上发展的替代治疗形式。事实上,以细胞因子为基础的治疗方法已被使用了许多年,在小部分患者中产生了良好的临床效应。在过去的几年中,免疫治疗以肾细胞癌的肿瘤相关抗原为试验靶点已被报道过,现综述以下几方面取得的研究进展,包括以细胞因子为基础的治疗,分子靶点、抗血管生成试剂治疗,RCC肿瘤相关性抗原和疫苗方案相关方面。
Renal cell carcinoma （RCC） is only mildly sensitive to classical radiotherapy or chemotherapy with poor prognosis. Immunotherapy is an alternative developed from the established and traditional treatment mode. In fact, cytokine-based therapy has been used for many years in a small proportion of patients With a good clinical effect. In the past few years, immunotherapy of tumor-associated antigen in renal cell carcinoma as test targets has been reported. Here, we summarize recent advances in cytokine-based therapy, molecular targets, anti-angiogenic agent therapy, tumor-associated antigen of RCC and vaccine programs.
出处
《临床泌尿外科杂志》
2013年第11期872-875,共4页
Journal of Clinical Urology
关键词
肾肿瘤
免疫治疗
kidney neoplasms
immunotherapy
