摘要
目的：探讨泌尿系小细胞癌的诊治方法、疗效及预后。方法：回顾性分析我院2003年1月～2012年12月收治的t1例泌尿系小细胞癌的病理、临床特征、诊断方法、治疗方法等资料，并对患者治疗效果、生存期等进行分析。结果：11例患者，男9例，女2例，平均年龄66．9（57～83）岁，肿瘤位于膀胱5例（1例为女性），右肾3例（1例为女性），左肾1例，前列腺2例。按TNM分期，膀胱肿瘤：T2bNnM01例，T2bN1M0 1例，2例均行根治性膀胱全切＋肠代膀胱术，分别于术后24个月及13个月死亡；T2bN2M1 1例，T3bN2M1 1例，此2例行根治性膀胱全切＋放疗＋化疗，分别于术后9个月、12个月死亡；T4N2M1 1例，行放疗＋化疗，3个月后死亡。肾脏肿瘤：T1aN0M01例，T1nN0M0 1例，T2bN1M0 1例，T3bN2M1 1例，均行根治性肾切除术＋放疗＋化疗，3例于术后6个月、13个月、24个月死亡，1例至今4年尚存活。前列腺肿瘤：T1cN0M1b 1例，行前列腺电切＋放疗＋化疗；T3bN1M1c 1例，行放疗＋化疗，随访时分别死于术后25个月及15个月。11例患者生存期最短3个月，目前最长48个月，平均17．5个月；1年生存率63．6％（7／11），5年生存率目前为0。结论：泌尿系小细胞癌恶性度高，预后差，手术联合放化疗可能会延长患者生存期、改善其生活质量。
Objective： To investigate the diagnosis, treatment and prognosis of small cell carcinoma of urinary tract. Method： The pathological and clinical data of 11 cases of small cell carcinoma in urinary tract from Jan 2003 to Dec 2012 were analyzed retrospectively. Moreover, the therapeutic effect and survival time were investigated. Result： Eleven cases included nine males and two females with an average age of 66.9 years. The tumor of five ca-ses were found in bladder （one female）, three cases in right kidney （one female）, one case in left kidney, two ca-ses in prostate. According to TNM staging, tumor of bladder T2b N0M0 was found in one case, T2b N1M0 was found in one case, both were treated with radical cystectomy and neobladder construction. The above two patients clied 24 months and 13 months respectively after the operation. Tumor of bladder T2b N2 M1 was shown in one case and TabN2M1 was seen in one case, who were treated with radical cystectomy combined with radiotherapy and chemotherapy. They died nine months and 12 months respectively after the operation. One case of bladder tumor T4 N2 M1 received radiotherapy and chemotherapy who died three months later. Tumor of kidney T1a N0 M0 was seen in one case, T1bN0M0 in one case and T2bN1M0 in one case, T3bN2M1 in one case as well. These four cases were treated with radical nephrectomy combined with radiotherapy and chemotherapy. Three of them died 6, 13, 24 months after the operation respectively. One of them has been alive for four years. Tumor of prostate T1c N0 M1b was observed in one case who was treated with transurethral resection of prostate plus radiotherapy and chemotherapy. The patient died 25 months later. Tumor of prostate T3b N1M1c was found in one case who was treated with radiotherapy and chemotherapy. This case died 15 months later. The survival time of 11 cases was from three months to 48 months （average of 17.5 months）. The survival rate was 63.6% （7/11） at one year and 0 at five years at present. Conclusion： The urinary
出处
《临床泌尿外科杂志》
2013年第11期822-825,共4页
Journal of Clinical Urology
关键词
膀胱
肾脏
前列腺
小细胞癌
bladder
kidney
prostate
small cell carcinoma
