摘要
目的:评估心力衰竭(心衰)合并睡眠呼吸暂停综合征(SAS)患者血清高迁移率族蛋白1(HMGB1)水平。方法:检测62例心衰合并SAS、62例单纯心衰患者及41例对照者的血清HMGB1、高敏C反应蛋白(hsCRP)和N端脑钠肽前体(NTproBNP)水平,同时评估患者的左室结构和功能。多元回归分析心衰合并SAS发病的危险因素。结果:心衰患者血清HMGB1、hsCRP和NT-proBNP,左房径、左室收缩末和舒张末径较对照组增加,而射血分数比对照组明显减少。心衰合并SAS患者的血清HMGB1、hsCRP水平又高于单纯性心衰患者。心衰患者血清HMGB1水平与左室收缩末和舒张末内径、NT-proBNP和hsCRP水平呈正相关。多因素回归分析显示HMGB1是心衰合并SAS发病的独立危险因素。结论:心衰合并SAS时血清HMGB1升高显著,且HMGB1是心衰合并SAS发病的独立危险因素。
Objective： To assess serum levels of high-mobility group box-1 protein （HMGB1） in patients with heart failure （HF） complicated by sleep apnea syndrome （SAS）. Methods：A total of 124 HF patients （62 SAS and 62 non-SAS patients） and 41 normal controls were enrolled in this study. Serum levels of HMGB1, high-sensitivity C-reactive protein （hsCRP） and N-terminal pro-brain natriuretic peptide （NT-proBNP） in parallel with left ventrieular structure and function were examined. Logistic multivariable regression was used to analyze the independent risk factors of HF concurrent SAS. Results：Serum levels of HMGBI, hsCRP and NT-proBNP were higher, and left atrial diameter, left ventricular end-diastolic and end-systolic diameters were larger in HF patients than those in controls. Left ventricular ejection fraction was lower in HF patients than that in controls. Serum levels of HMGB1 and hsCRP were elevated especially in SAS patients with HF compared with non-SAS patients with HF. HMGB1 levels positively correlated with left ventricular end-systolic and end-diastolic diameters, NT- proBNP and hsCRP. Multivariable regression analysis revealed that HMGB1 was an independent risk factor in HF patients with SAS. Conclusion： Serum level of HMGB1 is significantly elevated in HF patients with SAS, and it is an independent risk factor of this disease.
出处
《国际心血管病杂志》
2013年第6期397-399,403,共4页
International Journal of Cardiovascular Disease
