摘要
目的探讨PNPL43rs738409基因多态性与非酒精性脂肪性肝病（non—alcoholicfattyliverdiseas@，NAFLD）发生的关系。方法利用计算机在万方数据库、中国全文期刊数据库和维普数据库、Embase和Pubmed数据库中检索PNPLA3rs738409基因多态性与NAFLD发生的相关文献，并应用RevMan5．0软件对符合人选标准的文献进行异质性检验和效应值合并，同时进行敏感性分析和偏倚评估。结果纳入符合条件的相关文献11篇，共计NAFLD组1069例，对照组2127例。根据异质性检验结果，采用相应的效应模型进行合并分析。结果PNPLA3rs738409位点GC、CC、GC＋CC基因型与NAFLD的合并OR值（95％a）分别为0．63（0．36—1．12）、0．22（0．11～0．43）、0．50（0．15～1．66），Z=1．57、4．43、1．13，P〉0．05、〈0．05、〉0．05。各研究的敏感性分析较稳定且无发表偏倚。结论PNPLA3rs738409CC基因型与NAFLD的发生密切相关。
Objective To explore the relationship between patatin -like phospholipase domain containing3 （PNPLA3） rs738409 gene polymorphism and non - alcoholic fatty liver disease （NAFLD）. Methods The literature concerning PNPLA3 rs738409 gene polymorphism and non - alcoholic fatty liver disease was comprehensively retrieved in WanFang DATA , Chinese full - text journal databases, VIP database, Embase and Pubmcd database. The included literature was tested for heterogeneity, merging effect value, sensitivity analysis and bias evaluation with RevMan 5. 0 software. There were 11 pieces of literature included, which covered 1069 cases of NAFLD and 2127 cases of controls. The corresponding effect model was used for pooled analysis according to heterogeneity test results. Results For NAFLD, the pooled OR and 95% CI of gene type GC,CC,GC ＋ CC were 0.63（0.36 -1.12） （Z=1. 57, P 〉0.05）, 0.22（0.11 -0.43） （Z=4. 43, P 〈0.05）, and 0.50（0.15 - 1.66） （Z = 1.13, P 〉0.05） respectively. The sensitiveness analysis was stable and there was no publication bias. Conclusions PNPLA3 rs738409 CC gene type is closely related to the occurrence of NAFLD.
出处
《社区医学杂志》
2013年第20期8-10,共3页
Journal Of Community Medicine
