摘要
目的观察比较中草药与抗蛇毒血清治疗眼镜蛇咬伤患者效果及心肌酶谱变化情况。方法将眼镜蛇咬伤临床表现较严重的38例患者及一般的45例患者分别分为抗蛇毒血清治疗组及中草药治疗组,并对患者做治疗前和治疗后连续5 d的心肌酶谱检测观察统计分析。结果两组患者的心肌酶谱最早出现明显变化的是肌酸激酶(CK)参数,在治疗后的5 d中变化均比较大,而其它几项参数均在治疗后第1 d开始升高,如天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBD)、肌酸激酶同工酶(CK-MB)。抗蛇毒血清治疗组的各项心肌酶谱参数在治疗后的第4 d均恢复至当地正常人血清对照组参数,而中草药治疗组到第5 d有三项参数恢复至正常,而肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)虽然有明显下降,但仍未恢复到正常参数。结论抗蛇毒血清组患者心肌酶谱各项参数恢复至正常值优于中草药组,但两组患者经抢救和治疗均无死亡及致残患者并痊愈出院。
Objective To observe and compare the effects of Chinese herbal medicine with antivenin to treat cobra bite patients and changes of myocardial enzymes. Methods 38 cases bitten by cobra seriously and 45 cases bitten generally were divided into the antivenin treatment group and C, hinese herbal medicine treatment group. The cases were observed and analyzed for five consecutive days before treatment and detection of myo- cardial enzymes. Results The earliest significant changes of myocardial enzymes in the two groups was crea- tine kinase （CK） , which changed significantly in five days after treatment and several other parameters began to increase in the first days after the treatment, such as aspartate aminotransferase （AST） , lactate dehydro- genase （LDH） , alpha - hydroxybutyrate dehydrogenase （ α- HBD） and reatine kinase （ CK - MB） The myocardial enzymes parameters of antivenin treatment group restored to the local normal serum control group in the fourth day after treatment, while the three parameters of herbal treatment group restored to normal parame- ters till to the fifth day. Although creatine kinase （CK） and creatine kinase （CK- MB） had deereased sig- nificantly, they had not been restored to the normal parameters. Conclusions The restore of myocardial en- zymes parameters in antivenin group is superior to herbal medicine group but patients in the two groups were eured alter the treatment, and there was no death and disability.
出处
《医学动物防制》
2013年第11期1189-1191,共3页
Journal of Medical Pest Control
