摘要
药物性肝损伤(DILI)可分为直接肝毒性和特异质性肝损伤(IDILI)。IDILI发生率较低,个体发病存在易感因素,在动物模型中很难复制。同时,IDILI缺乏可靠的临床诊断标准,使其发病机制的研究受到限制。近年来关于IDILI的发病机制,主要在遗传易感性、代谢途径、宿主免疫、线粒体毒性和胆道损伤等方面取得进展,各种发病机制的深入研究和相互关系的阐明,或将揭示IDILI的真正致病机制。
Drug- induced liver injury （DILI） is divided into two types, terms as ＇ intrinsic＇ and ＇ idiosyncratic ＇. Idiosyncratic drug-induced liver injury （IDILI） is typically rare and requires one or more susceptibility factors in individuals. Consequently, it has been difficult to reproduce in animal models. At the same time, IDILI lack a reliable clinic diagnostic criteria, which has limited the understanding of its underlying mechanisms. There have some recent advances in the etiopathogenesis of IDILI, which including genetic factors, reactive metabolites, host immune-response pathways, mitochondrial toxicity and biliary iniury. Further research on these mechanisms and their relationship may help to reveal the pathogenesis of IDILI.
出处
《医学与哲学（B）》
2013年第10期14-16,共3页
Medicine & Philosophy(B)
关键词
药物性肝损伤
发病机制
肝毒性
特异质性肝损伤
drug- induced liver injury（DILl）, mechanisms, hepatotoxicity, idiosyncratic drug- induced liver iniury（IDILI）
