摘要
目的探讨T2DM患者血清巨噬细胞抑制因子-1(MIC-1)与颈动脉粥样斑块的相关性。方法根据多普勒超声结果,将113例T2DM患者分为合并颈动脉粥样斑块组(A,n=55)与单纯T2DM组(B,n=58),另选正常对照组(C,n=57)。ELISA测定研究对象血清MIC-1水平。结果 A、B组血清MIC-1水平高于C组(P<0.01),A组高于B组(P<0.01)。相关分析显示,血清MIC-1水平与FPG、HbA1c、SBP、DBP、TG、肿瘤坏死因子α(TNF-α)呈正相关(r=0.183、0.287、0.173、0.194、0.270、0.287,P<0.05),与HDL-C呈负相关(r=-0.410,P<0.01)。多元线性逐步回归分析表明,HbA1c、TG、HDL-C是血清MIC-1水平的独立影响因素(β=0.204、0.176、-0.296,P<0.05)。结论 T2DM患者血清MIC-1水平升高,T2DM合并颈动脉粥样斑块患者血清MIC-1水平较单纯T2DM患者进一步升高。HbA1c、TG、HDL-C是MIC-1的独立相关因素。
Objective To explore the correlation between serum macrophage inhibitory cytokine-1 （MIC-1） and carotid plaque in type 2 diabetic patients.Methods A total of 113 cases was divided into two groups：T2DM patients with carotid plaque group（A,n=55）,and without carotid plaque group（B,n=58） according to the results of Doppler echocardiography.Fifty-seven healthy people were selected as normal control group （C,n=57）.Serum MIC-1 levels were detected by ELISA.Results The levels of MIC-1 in group A and B were significantly higher than in group C （P＜0.01）.Compared with group B,the level of MIC1 in group A was increased（P＜0.01）.Correlation analysis showed that serum MIC-1 levels was positively correlated with fasting plasma glucose、glycosylated hemoglobin A1c （HbA1c）、systolic blood pressure （SBP）、diastolic blood pressure（DBP）、triglycerides （TG） 、tumor necrosis factor-α （r =0.183,0.287,0.173,0.194,0.270,0.287,P＜0.05）,and it was inversely related to high-density-lipoprotein cholesteROl（HDL-C）（r=-0.410,P＜0.01）.Stepwise linear multiple regression analysis showed that HbA1c,TG and HDL-C were the independent factors of serum MIC-1（β=0.204、0.176、-0.296,P＜0.05）.Conclusion The levels of serum MIC-1 in T2DM patients are higher,and they are even higher in T2DM patients with carotid plaque.HbA1 c,TG and HDL-C are the independent correlative factors of serum MIC-1.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2013年第11期973-975,共3页
Chinese Journal of Diabetes
关键词
糖尿病
2型
巨噬细胞抑制因子-1
颈动脉
粥样斑块
Diabetes mellitus, type 2
Macrophage inhibitory cytokine-1 （MIC-1）
Carotid artery
Atheromatous plaque
