摘要
胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)的重要病理生理改变。IR及高胰岛素血症是PCOS患者代谢异常的基本特征,也是PCOS患者内分泌代谢紊乱的主要特征之一。肥胖型PCOS患者高胰岛素血症发生率高达75%,非肥胖型PCOS患者约为30%。流行病学调查显示PCOS患者发生2型糖尿病、高血压、冠心病等疾病的风险明显增加,胰岛素抵抗可能在PCOS的发生中起着重要作用。生活方式改变和胰岛素增敏剂是治疗的有效方法。
Insulin resistance (IR) is the important physiopathologic change. IR and hyperinsulinemia are the basic characteristics of polycystic ovary syndrome (PCOS) , and they are also one of the main characteristics of PCOS patients with endocrine and metabolic disorders. The rate of hyperinsulinemia of the PCOS patients with obesity are about 75% , and 30% with none obesity patients. According to epidemiological investigation, the morbidity of non - insulin dependent diabetes mellitus(NIDDM) , hypertension and coronary heart disease increase in PCOS patients. IR may play an important role in pathogenesis of PCOS. Lifestyle modification and using insulin sensitizer are effective measures of PCOS with IR.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2013年第11期864-866,共3页
Chinese Journal of Practical Gynecology and Obstetrics