摘要
采用放免分析等方法 ,研究了菟丝子的黄酮类提取物对下丘脑 -垂体 -性腺轴的影响。结果表明它具有雌激素样活性 ;可使成年大鼠腺垂体、卵巢、子宫重量增加 ;增强卵巢人绒毛促性腺激素 (hCG) /黄体生成素 (LH)受体功能及垂体对促性腺激素释放激素 (LRH)的反应性 ;促进离体培养人早孕绒毛组织hCG分泌 ;增加未成年雄性小鼠睾丸、附睾重量 ;促进离体培养大鼠睾丸间质细胞睾酮的分泌。提示菟丝子有改善生殖内分泌的功能。
Semen Cuscutae is a kidney-essence invigorating Chinese drug which is widely used in the clinic. In this study, the effects of the flavonoids extracted from Semen Cuscutae (FSC) on the function of the hypothalamus-pituitary-gonads axis in animals was investigated. The results showed that FSC can increase the weight of uterus and promoted the cornification of vaginal epithelial cells in bilateral ovariectomized mice, which suggested that FSC may have estrogen-like activity. In normal female rats, it increased the weight of pituitary, ovary and uterus, but did not increase plasma luteinizing hormone (LH) level. The binding capacity of ovary to 125 I-HCG/LH receptor was significantly elevated the reactivity of luteinizing-releasing hormone (LRH) was increased, and the LRH-induced LH secretion was enhanced in ovariectomized rats. In immature male mice, FSC increased the weight of epididymis and testis, and stimulated HCG-induced secretion of testosterone in short-term cultured rat Leydig cells. It is suggested that FSC can improve the functions of reproductive and endocrine system.
出处
《中药新药与临床药理》
CAS
CSCD
2000年第6期349-351,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药管理局课题(项目号:97255)
