摘要
目的观察多沙唑嗪联合双氯芬酸钠栓剂治疗前列腺等离子电切术后膀胱痉挛的效果。方法采用随机对照单盲临床实验设计，将入选的200例经尿道前列腺等离子电切术术后患者随机分为4组。A组（50例）于手术后即刻肛门塞双氯芬酸钠栓剂100mg，每12h1次，麻醉清醒后口服多沙唑嗪4mg／d；B组（50例）术后即刻肛门塞双氯芬酸钠栓剂100mg，每12h1次；c组（50例）术后麻醉清醒后口服多沙唑嗪4mg／d；D组（50例）术后不予预防性应用双氯芬酸钠栓剂及多沙唑嗪，均为手术后3d停药。结果A组术后每天平均膀胱痉挛次数[第1天：（O．47±0．18）次；第2天：（O．35±0．16）次；第3天：（O．30±0．20）次]、膀胱痉挛平均持续时间[第1天：（3．2±1．5）min；第2天：（2．1±1．3）min；第3天：（1．4±1．2）min]、膀胱持续冲洗液转淡时间（1．5±0．3）d、拔除导尿管时间（4．0士0．5）d与D组比较均少和短，均P〈0．05。B组、c组的各组分别与D组相比较也均少和短，均P〈0．05。结论多沙唑嗪联合双氯芬酸钠栓剂治疗前列腺等离子电切术后膀胱痉挛具有良好的效果。
Objective To observe the clinical effect of doxazosin combined with diclofenac sodium in the treatment of bladder spasm after transurethral bipolar plasmakinetic prostatectomy （TUPKP）. Methods 200 BPH patients undergoing TUPKP were randomly divided into 4 groups according to single-blind randomized controlled trial design： group A, group B, group C, group D （n =50, each）. Patients in group A were given diclofenac sodium 100 mg, q12h, in anus after surgery and doxazosin 4 mg/d orally after anesthetic awareness. Patients in group B were given diclofenac sodium in anus 100 mg, q 12h in anus after surgery. Patients in group C were given doxazosin 4 rag/ d orally after anesthetic awareness. Patients in group D were not given diclofenac sodium and doxazosin. Drugs were withdrawn 3 days after surgery. Results In group A, the average time of bladder spasm was （0.47±0.18） time, （0.35±0.16） time, （0.30±0.20） time at the 1st, 2 nd, 3 rd day respectively the duration of bladder spasm was （3.2±1.5） min, （2.1±1.3） rain, （1.4±1.2） min at the 1st, 2nd, 3th day respectively; the time of bladder perfusion clearance was （1.5±0.3）days and the time of urethral catheter removal was （4.0±0.5） days. There were significant differences in above observed values between group D and the other groups （all P〈0.05）. Conclusions Doxazosin combined with diclofenae sodium therapy is effective in the treatment of bladder spasm after bipolar transurethral plasmakinetic prostatectomy.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第11期1209-1211,共3页
Chinese Journal of Geriatrics
关键词
多沙唑嗪
膀胱疾病
经尿道前列腺切除术
Doxazosin
Urinary bladder diseases
Transurethral resection of prostate
