摘要
巴戟天为茜草科植物巴戟天（MorindaofficinalisHow．）的干燥根，具有补。肾阳、强筋骨、祛风湿之功效，但是对其补肾阳作用的研究却鲜有报道[列。目前肾阳虚证模型的制作方法主要有西医病因病理法f如糖皮质激素应用法、甲状腺切除法、去势法、羟基脲灌胃法等）和模拟传统病因法（如恐伤肾致肾（阳）虚动物模型、老年肾阳虚动物模型、房劳伤肾动物模型等）。
To investigate the intervention effects of Morinda officinalis How. on ＇Kidney-yang deficiency syndrome＇ induced by hydrocortisone in rats, the metabolic profiles of rat urine were characterized using proton nuclear magnetic resonance and principal component analysis （PCA） was applied to study the trajectory of urinary metabolic phenotype of rats with ＇Kidney-yang deficiency syndrome＇ under administration of M. officinalis at different time points. Meanwhile, the intervention effects of M. officinalis on urinary metabolic potential biomarkers associated with ＇Kidney-yang deficiency syndrome＇ were also discussed. The experimental results showed that in accordance to the increased time of administration, an obvious tendency was observed that clustering of the treatment group moved gradually closed to that of the control group. Eight potential biomarkers including citrate, succinate, a-ketoglutarate, lactate, betaine, sareosine, alanine and taurine were definitely up- or down-regulated. In conclusion, the effectiveness of M. officinalis on ＇Kidney-yang deficiency syndrome＇ is proved using the established metabonomic method and the regulated metabolic pathways involve energy metabolism, transmethylation and transportation of amine. Meanwhile, the administration of M. officinalis can alleviate the kidney impairment induced by ＇Kidney-yang deficiency syndrome＇.
出处
《药学学报》
CAS
CSCD
北大核心
2013年第11期1733-1737,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81173194
81274059)
广东省科技计划项目(2012B060300031)
关键词
代谢组学
核磁共振
肾阳虚证
巴戟天
metabonomics
NMR
Kidney-yang deficiency syndrome
Morinda oJficinalis How.
