摘要
目的探讨血栓通注射液对慢性阻塞性肺疾病急性发作期(AECOPD)患者血栓前状态的影响及其临床意义。方法将80例AECOPD患者随机分为治疗组和对照组各40例,2组均予西药常规治疗,治疗组加用血栓通注射液,疗程均为10 d,比较各组治疗前后血液流变学、凝血功能及D-二聚体等指标水平变化。数据分析采用SPSS 13.0统计软件包进行统计分析。结果治疗组及对照组治疗后较治疗前活化凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)延长,FIB、D-二聚体降低(P<0.01),血液流变学指标均有明显降低(P<0.05),治疗组改善均优于对照组(P<0.05),未见不良反应。结论血栓通注射液可以有效干预AECOPD患者的血栓前状态。
Objective To explore the change and significance of Xueshuantong injection on the prethrombotic state in patients with acute episode chronic occlusive pulmonary disease（AECOPD）.Methods 80 patients with AECOPD were selected and randomly divided into two groups.One was a comparison group in which 40 patients were treaed with conventional therapy.The other was Xueshuantong group in which 40 patients received both the same treatment mentioned above and intravenous infusion of Xueshuantong injection.All the treatment duration lasted for 10 days.The blood rheology indexes,coagulation function and the the two D-dimer level were detected respectively in each group,both before and after treatment. SPSS13.0 statistical data analysis software package was used.Results After treatment,the level of activated partial thromboplastin time（APTT）,thrombin time（TT）,prothrombin time（PT） prolonged,and the level of fibrinogen and the two Ddimer significandy decreased（P〈0.01）.The blood rheology indexes were also lower than before（P〈0.05）.The result of treatment group is better than control group（P〈0.05）,no adverse reaction found.Conclusion Xueshuantong injection can effective improve the prethrombotic state in patients with acute episode chronic occlusive pulmonary disease（AECOPD）. Xueshuantong injection can effective interfere the prethrombotic state in patients with AECOPD.
出处
《长春中医药大学学报》
2013年第5期788-789,共2页
Journal of Changchun University of Chinese Medicine
