摘要
目的探讨雌激素对绝经后妇女脂代谢的影响。 方法 2 5例绝经后妇女 ,其中 15例为口服结合雌激素组 (研究组 ) ,10例为不用药组 (对照组 ) ,观察血浆总胆固醇 (TC)、甘油三脂 (TG)、高密度脂蛋白 -胆固醇 (HDL-C)、低密度脂蛋白 -胆固醇 (LDL -C)和α -脂蛋白 (α -Lp)及TC/HDL -C、LDL -C/HDL -C比值的变化 ;观察研究组血清FSH、LH、E2 和E1的变化。 结果激素替代疗法 (HRT)后 ,HDL -C随用药时间的延长上升 ,TC/HDL-C及LDL -C/HDL -C比值明显降低 ,α-LP下降 ,尤其在第 6个月后。研究组血清FSH和LH 3个月后即显著下降 ,而E2 和E1明显升高 (P <0 .0 1)。 结论绝经后妇女使用雌激素 0 .6 2 5mg/d ,合并安宫黄体酮 4mg/d对升高HDL -C ,降低TC/HDL -C、LDL -C/HDL -C比值与α-LP的下降起着有益的作用 ,从而对绝经后妇女冠心病的发生起到预防作用。
s: Objective To investigate the effect of hormone replacement therapy on plasma lipid and lipoprotein metabolism. Methods 25 healthy postmenopausal women were studied. 15 women were given conjugated estrogen (CE) 0.625mg/d and medroxyprogesterone acetate (MPA) 4mg/d for 12 months (HRT group) while 10 cases didn't receive any hormonal medication (control group). The plasma levels of total cholesterol (TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C) and α-lipoprotein (α-Lp) were evaluated at 0,3,6,and 12month, respectively, and plasma FSH, LH, E 2, and E 1 levels were measured at the same point in both groups. Results In HRT group TC and TG levels were slightly increased, but no significant difference was detected. HDL-C was significantly increased in HRT group while TC/HDL-C and LDL-C/HDL-C ratios were significantly dereased. FSH and LH levels were lowered, howerver E 2 and E 1 levels were elevated at 3 month (P<0.01). Conclusion Hormone replacement therapy has a potential protective effect on decreasing the morbidity of coronary heart disease in postmenopausal women by increasing plasma HDL-C level and decreasing TC/HDL-C and LDL-C/HDL-C ratios
出处
《上海第二医科大学学报》
CSCD
2000年第6期544-546,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
绝经
雌激素替代疗法
血脂
postmenopause hormone replacement therapy plasma lipid
