摘要
[目的]研发适合工业化生产氯虫苯甲酰胺关键中间体2-氨基-5-氯-N,3-二甲基苯甲酰胺的工艺。[方法]以3-甲基-2-硝基苯甲酸为起始原料,经加氢、环合、胺解和氯化4步反应得到目标化合物。[结果]4步反应总收率为77.6%,产品含量为98.3%。[结论]该方法原料廉价易得、操作简单、反应条件温和,具有工业化应用前景。
[Aims] A synthetic method of 2-amino-5-chloro-N,3-dimethylbenzamide suitable on industrial scale was improved. [Methods] The title compound was synthesized from 3-methyl-2-nitro-benzoic acid via hydrogenation, cyclization, methylamination and chlorination. [Results] The total yield of the 4 synthetic steps reached 77.6% and the product purity reached 98.3%. [Conclusions] The improved method has such advantages as cheap and ready available raw materials, simple operations and warm reacting conditions. It is valuable to be used in industrial scale.
出处
《农药》
CAS
CSCD
北大核心
2013年第11期793-795,811,共4页
Agrochemicals
