摘要
目的:探讨卵巢型子宫内膜异位症腹腔镜保守性手术后辅助曲普瑞林及孕三烯酮不同用药时间对复发的影响。方法:对345例卵巢型子宫内膜异位症患者行腹腔镜保守性手术,术后根据用药情况分为5组:未用药组92例,GnRH-a 3个月组77例和6个月组70例,孕三烯酮3个月组53例和6个月组53例。观察比较各组的复发情况及复发时间,计算年复发率及累计复发率。结果:术后第1、2、3年累计复发率分别为8.69%、20.58%、23.12%,其中用药组为17.78%,低于未用药组的38.04%(P<0.05);GnRH-a 3个月组(22.07%)、GnRH-a 6个月组(10.00%)、孕三烯酮6个月组(11.32%)的三年累计复发率均低于未用药组(P<0.05),孕三烯酮3个月组(28.30%)与未用药组比较无统计学差异(P>0.05);GnRH-a 6个月组三年累计复发率低于3个月组,孕三烯酮6个月组低于3个月组(P<0.05)。术后复发时间GnRH-a 6个月组为(20.00±4.61)月,孕三烯酮6个月组为(19.17±4.07)月,均低于未用药组的(13.43±3.01)月(P<0.05);GnRH-a 3个月组为(15.88±5.83)月、孕三烯酮3个月组为(15.20±5.43)月,与未用药组比较无统计学差异(P>0.05);GnRH-a 6个月组术后复发时间低于3个月组、孕三烯酮6个月组低于3个月组(P<0.05)。结论:术后使用药物GnRH-a及孕三烯酮的平均时间少于3个月均不能延缓复发,但GnRH-a可减少复发,孕三烯酮不能减少复发;而术后使用药物GnRH-a及孕三烯酮6个月均可减少复发并在一定程度上延缓复发。
Objective：To explore the effects of different drugs and medication times of triptorelin and gestrinone on recurrence of o- varian endometriosis after laparoscopic conservative surgery. Methods：A total of 345 patients with ovarian endometriosis underwent laparo- scopic conservative surgery, and then they were divided into five groups according to postoperative medication situations： control group （92 patients）, three - month-GnRH - a treatment group （77 patients）, six - month - GnRH - a treatment group （70 patients）, three - month - gestrinone treatment group （53 patients）, and six -month -gestrinone treatment group （53 patients）. The recurrence situations and times in the five grotlps were observed and compared, the annual recurrence rates and accumulative recurrence rates were calculated in the five groups. Results：The accumulative recurrence rates on the first year, the second year, and the third year after surgery were 8.69%, 20. 58% , and 23.12% , respectively; the mean accumulative recurrence rate in treatment groups was 17.78%, which was statistically sig- nificantly lower than that in control group （ 38.04% ） （ P 〈 0. 05 ） ; the three - year accumulative recurrence rates in three-month-GnRH-a treatment group （22. 07% ） , six - month - GnRH - a treatment group （ 10. 00% ） , and six - month - gestrinone treatment group （ 11. 32% ） were statistically significantly lower than that in control group （ P 〈 0. 05 ） ; there was no statistically significant difference in the three - year accumulative recurrence rate between three - month - gestrinone treatment group （28.30%） and control group （ P 〉 0. 05 ） ; the three - year accumulative recurrence rate in six - month - GnRH - a treatment group was lower than that in three - month - GnRH - a treatment group, and the three - year accumulative recurrence rate in six - month - gestrinone treatment group was lower, than that in three - month - gestri- none treatment group, there were statistically signifi
出处
《中国妇幼保健》
CAS
北大核心
2013年第32期5374-5376,共3页
Maternal and Child Health Care of China
