摘要
目的:比较天然黄体酮对先兆流产乙肝患者不同用药方式的疗效。方法:56例妊娠早期先兆流产乙肝携带患者随机分为3组,阴道给药组(外用组)30例,天然黄体酮(P)胶囊阴道给药,口服组26例,口服P胶囊,并选择同期未使用任何药物的无先兆流产的早孕乙肝患者16例作为对照组。动态监测血清P和人绒毛膜促性腺激素(HCG)的变化,保胎至12周为成功,观察阴道给药组和口服组的保胎成功率。结果:56例中保胎成功47例,口服给药组保胎成功率84.6%,阴道给药组成功率83.3%。初次治疗1周,两治疗组血清P的日均增长值显著高于对照组(P<0.01),HCG的日均增长量组间比较无显著性差异(P>0.05)。后续治疗期间P和HCG的日均增长量组间比较均无显著性差异(P>0.05)。结论:天然黄体酮口服给药和阴道给药对治疗先兆流产均有良好疗效,且阴道给药乙肝患者可以减轻早孕反应,降低药物性肝损害。
Objective：To compare the efficacy of different routes of administration by using the natural progesterone to threatened abortion hepatitis B patients.Method：Early pregnancy hepatitis B patients with threatened abortion were randomized into vaginal administration group,30 cases of natural progesterone（P）capsules administered vaginally,orally group of 26 patients with oral P capsule and select early pregnancy hepatitis B patients without threatened abortion 16 cases as the control group.Development monitoring of serum P and human chorionic gonadotropin（HCG）were measured before and after treatment.Observe vaginal administration group and oral group miscarriage successful rate.Results：There were successes of 47 cases in 56 cases of threatened abortion.In oral administration group,the tocolytic successful rate was 84.6％,and that was 83.3％ in the vaginal administration power group.The initial treatment of one week,the average daily growth of the two treatment groups P value was significantly higher than that in the control group（P ＜0.01）;the average daily increase in the amount of HCG groups showed no significant difference（P ＞ 0.05）.In the continue medication miscarriage patients after one week of treatment,average daily increase in the amount of P and HCG groups showed no significant difference（P ＞ 0.05）.Conclusion：The natural progesterone administered orally and vaginal administration have a good effect on the treatment of threatened abortion,vaginal administration better to lighten morning sickness and hepatic lesion.
出处
《中医药信息》
2013年第5期101-103,共3页
Information on Traditional Chinese Medicine
关键词
先兆流产
乙肝患者
给药途径
天然黄体酮
Threatened abortion
Hepatitis B patients
Route of administration
Natural progesterone
