摘要
目的探讨甲氨蝶呤联合环磷酰胺治疗类风湿关节炎(RA)对患者血清白细胞介素-21(IL-21)的影响。方法选择本院70例RA患者,采用甲氨蝶呤联合环磷酰胺静脉滴注治疗,观察患者治疗后自身抗体阳性组与阴性组血清IL-21水平及第6、12、24周血清IL-21水平变化情况。结果本组患者RF-IgM、RF-IgA和抗CCP抗体阳性组患者血清IL-21水平均明显高于阴性组患者,差异有统计学意义(P<0.05);患者治疗后第6、12、24周血清IL-21检测指标呈下降趋势,治疗第12、24周时血清IL-21水平明显低于入院时,差异有统计学意义(P<0.05或P<0.01)。结论甲氨蝶呤联合环磷酰胺治疗RA临床疗效显著,可明显降低血清IL-21水平。
Objective To explore the influence of the methotrexate （MTX） combined with cyclophosphamide （CTX） on serum IL-21 level for patients with rheumatoid arthritis （RA）. Methods 70 cases of RA patients in our hospital were selected, and all the patients were treated by MTX combined with CTX, serum IL-21 in antibody positive group and negative group were compared and levels of IL-21 in the 6, 12, 24 weeks were observed. Results IL-21 level in patients with RF-IgM and RF-IgA and anti CCP antibody positive were significantly higher than those in the negative group, the difference was significant （P〈0.05）; After 6, 12, 24 weeks treatment, serum IL-21 in three groups decreased significantly, and was significantly lower than that on admission, the difference was significant （P〈0.05 or P〈0.01）. Conclusion Treatment of methotrexate combined with cyclophosphamide has distinctive effect on RA treatment and it can significantly reduce the serum level of IL-21.
出处
《中国当代医药》
2013年第30期74-75,共2页
China Modern Medicine
