摘要
目的 探讨前哨淋巴结活检术（SLNB）替代腋窝淋巴结清扫术（ALND）在早期乳腺癌患者治疗中的应用价值和安全性.方法 应用亚甲蓝行SLNB,2004年1月～2008年1月收治入院的临床T1-2NoM0乳腺癌患者100例入选本研究,所有患者均签署知情同意书,不同意SLNB替代ALND治疗的50例患者为A组,同意SLNB替代ALND治疗的50例患者为B组.依据前哨淋巴结（SLN）状况,对SLN阴性者仅行SLNB,SLN阳性者行AL-ND,比较分析两组间术后并发症和术后生存率的状况.结果 B组术后1、3年生存率分别为100％（100/100）、100％（100/100）,A组术后1、3年生存率分别为100％（100/100）、82％ （82/100）,两组3年生存率比较差异有统计学意义（P＜0.05）;B组并发症发生率明显低于A组,两组比较差异有统计学意义（P＜0.05）.结论 SLNB可以指导临床开展缩小腋区淋巴清扫范围的手术,从而有效减轻手术创伤和术后并发症.早期乳腺癌手术中SLNB对术中指导乳腺癌手术范围有较大价值.
Objective To investigate the value and safety of sentinel lymph node biopsy （SLNB） replace alternative axillary lymph node dissection （ALND） in the treatment of early breast cancer.Methods Methylene blue was used for SLNB,100 cases of patients with breast cancer （T1-2NoMo） from January 2004 to January 2008 admitted to our hospital were enrolled in the study.All patients signed an informed consent,50 cases of patients who did not agree with SLNB replacement therapy were selected as group A;50 cases of patients who agreed with SLNB replace were selected as group B,according to the sentinel lymph node （SLN） status,patients with negative SLN were only given SLNB,patients with positive SLN underwent ALND,postoperative complications and survival situation between the two groups were compared.Results 1-year,3-year survival rate of group B was 100% （100/100）,100% （100/lO0）,and 1-year,3-year sur- vival rate of group A was 100% （100/100）, 82% （82/100）,3-year survival rate of two groups compared,the difference was significant （P〈O.OS）;the complication incidence of group B was significantly lower than that of group A,the differ- ence was significant （P〈0.05）.Conclusion SLNB can guide for narrowing the scope of ALND,effectively reducing surgi- cal trauma and postoperative complications.It has great value in intraoperative guidance of breast cancer surgery range.
出处
《中国当代医药》
2013年第30期31-32,34,共3页
China Modern Medicine
