摘要
目的 应用FloTrac/Vigileo监测系统探讨活体肝移植患者术中血流动力学变化规律,为临床麻醉管理提供参考.方法 肝移植患者28例,静吸复合全麻下行活体部分肝移植术.分别于切皮前即刻(T0)、无肝期5 min(T1)、无肝期30 min (T2)、新肝期5min(T3)、新肝期30min(T4)和术毕(T5)记录心率(HR)、平均动脉压(MAP)、心排量(C0)、心脏指数(CI)、每搏量(SV)、每搏变异度(SVV)等指标.结果 与To比较,患者HR在T1~5升高(P<0.01);MAP、CO、CI和SV于T1~4降低(P均<0.01),T5时恢复至切皮前水平(P >0.05);SVV于T1~2升高(P<0.01),T3~4降低(P<0.05),T5恢复至切皮前水平(P>0.05).结论 活体肝移植患者无肝期和新肝再灌注早期循环抑制明显,应根据不同时期机体对容量负荷的反应性合理输液,并进行有效的循环支持.
Objective To investigate the characteristics of hemodynamic changes in adult patients undergoing living donor liver transplantation (LDLT) with FloTrac/Vigileo monitoring. Methods 28 recipients who underwent right lobe adult - to - adult LDLT received general anesthesia. Hemodynamic parameters including heart rate ( HR), mean arterial pressure ( MAP), cardiac output (CO), cardiac index (CI), stroke volume (SV) and stroke volume variation (SVV) were recorded before skin incision ( To ) , at 5 rain ( Tl ) and 30 min ( T2 ) of anhepatic phase, 5 min ( T3 ) and 30 min (T4) of neohepatic phase and the end of surgery (T5 ). Results Compared with To, the HR increased at T1-5 (P 〈 0.01 ). The MAP, CO, CI and SV decreased at T1-4 (P 〈0.01 ). returned to the baseline at T5 ( P 〉 0.05 ). The SVV increased at T1-2 ( P 〈 0.01 ), decreased significantly at T3 -4 ( P 〈 0.05 ), returned to the basline at Ts (P 〉 0.05). Conclusion Remarkable changes in hemodynamics of LDLT were found, especially in the anhepatic and neohepatic phase.
出处
《中国急救医学》
CAS
CSCD
北大核心
2013年第11期999-1001,共3页
Chinese Journal of Critical Care Medicine
基金
2012年天津医学会麻醉学分会中青年科研培育基金项目
天津市卫生局科技基金项目(201lKYl2)