摘要
目的探讨哌拉西林/他唑巴坦治疗术后腹腔感染的临床效果,为患者术后腹腔感染提供更好的治疗方法。方法选取新疆维吾尔自治区人民医院2010年12月~2012年12月收治的150例术后腹腔感染的患者进行研究。按照数字随机的方法将患者分为两组,每组75例。观察组采用哌拉西林/他唑巴坦治疗,静滴剂量为每次4.5 g,q8h^q12h,疗程5~10 d。对照组给予静脉滴注0.4 g环丙沙星注射液+0.5 g甲硝唑注射液,1~2次/d,疗程5~14 d,观察比较两组患者治疗后的疗效、细菌耐药情况以及患者的细菌清除率及住院时间。结果对照组术中留取标本耐药率为6.67%(5/75),观察组术中留取标本耐药率为22.67%(17/75)。除去耐药病例数,观察组总有效率[91.43%(64/70)]显著高于对照组[55.17%(32/58)]。观察组清除89株,清除率为84.8%,而对照组清除53株,清除率为49.1%,两组相比,差异有统计学意义(P<0.05)。结论在复杂腹腔内感染的治疗中,哌拉西林/他唑巴坦作为经验性药物和确定性药物,单用的效果均明显优于环丙沙星联合甲硝唑,应作为腹腔内感染治疗的一线用药。
Objective To study the efficacy of Piperacillin/Tazobactam on postoperative abdominal infection, and to provide a better way to treat postoperative abdominal infection. Methods 150 patients with postoperative abdorninal infection from De-cember 2010 to December 2012 in the People＇s Hospital of Xinjiang Uighur Autonomous Region were studied. They were di-vided into two groups. Each group had 75 cases. The observation group was treated with Piperacillin/Tazobactam, which was intravenous dosage of 4.5 g, qSh-q12h, 5-10 d. The control group was treated with Ciprofloxacin Injection 0.4 g＋0.5 g Metronidazole Injection intravenously, 1-2 times/d, for 5-14 d. After treatment, the efficacy and bacterial drug resistance; and the patient＇s bacterial clearance rate and hospitalization time comparisons would be observed. Results The drug resistance rates of control group and observation group were 6.67% （5/75） and 22.67% （17/75）. Except for the number of resistant cases, the total effective rate of observation group was 91.43% （64/70）, significantly higher than 55.17% （32/58） of control group. Observation group cleared away 89 plants, clearance rate was 84.8%, while the control group cleared away 53 plants, clear- ance rate was 49.1%. Compared to the two groups, the differences were significant （P 〈 0.05）. Conclusion Whether as a treatment of complicated intra-abdominal infections empirical drug, or certainty drugs, Piperacillin/Tazobactam alone is sig-nificantly better than the effect of Ciprofloxacin combined with Metronidazole, which should be treated as intra-abdominal in-fections first-line treatment.
出处
《中国医药导报》
CAS
2013年第30期107-109,共3页
China Medical Herald
关键词
术后腹腔感染
哌拉西林
他唑巴坦
手术
Postoperative abdominal infection
Piperacillin/Tazobactam
Surgery
