摘要
目的 探讨系统性红斑狼疮（systemic lupus erythematosus,SLE）患者尿微量蛋白的变化及临床意义.方法 选择52例SLE患者（SLE组）和40例健康志愿者（对照组）,分别检测其尿常规（尿蛋白定性）和尿α1-微球蛋白（α 1-MG）、N-乙酰-β-D-葡萄糖苷酶（NAG）、β2-微球蛋白（β2-MG）、转铁蛋白（TRF）、微量白蛋白（MA）及免疫球蛋白G（IgG）,同时检测血清肌酐（Cr）；并对检测结果和各指标的阳性检出率进行统计分析.结果 SLE组尿α1-MG、NAG、β 2-MG、TRF、MA和IgG显著升高,与对照组比较差异有统计学意义（P＜0.01）.SLE组六项尿微量蛋白指标联合检测的阳性率明显高于血清Cr （P＜0.01）.尿α1-MG、NAG和β 2-MG三项联合检测的阳性率明显高于尿TRF、MA和IgG三项联合检测（P＜0.05）.单项指标的阳性检出率,尿IgG和尿TRF高于尿MA（P＜0.01,P＜0.05）,尿α 1-MG和尿β 2-MG高于尿NAG（P＜0.01,P＜ 0.01）.结论 SLE患者尿α 1-MG、NAG、β 2-MG、TRF、MA和IgG显著升高,适用于SLE患者肾功能损伤的早期诊断；SLE患者肾小管功能损伤的概率大于肾小球的功能损伤.在反映SLE患者肾小球功能损伤的指标中,尿IgG和尿TRF优于尿MA;在反映SLE患者肾小管功能损伤的指标中,尿β 2-MG和尿α1-MG优于尿NAG.
Objective To study the changes of urinary trace protein levels in patients with systemic lupus erythematosus（SLE） and its clinical significance.Methods The levels of urinary α 1-microglobulin （α 1-MG）,β 2-microglohulin（β 2-MG）,transferrin（TRF）,microalbumin（MA）,and immunoglobulin G（IgG）were detected by immunturbidimetry,N-acetyl-β-D-glucoseaminidase enzyme（NAG） was detected by biochemistry,and serum creatinine （Cr） was detected in 52 patients with SLE（SLE group） and 40 healthy volunteers（control group）.The data was analyzed by IBM SPSS Statistics.Results The levels of ot 1-MG,NAG,β 2-MG,TRF,MA,and IgG were significantly higher in the SLE group than in the control group （P ＜ 0.01）.The positive rate of combined detection of urinary trace proteins was higher than that of serum Cr （P ＜ 0.01）.There was a statistical difference between the positive rate of combined detection of o 1-MG,NAG,and β 2-MG and the positive rate of combined detection of TRF,MA,and IgG in patients with SLE（P ＜ 0.05）.The positive rates of IgG and TRF were higher than that of MA（P ＜ 0.05,P ＜ 0.05）.The positive rates of β 2-MG and o 1-MG were higher than that of NAG（P ＜ 0.01,P ＜ 0.01）.Conclusions Urinary o 1-MG,NAG,β 2-MG,TRF,MA,and IgG levels increase in patients with SLE and can be applied on early diagnosing the renal function injury of the patients with SLE.The patients with SLE are more likely to have renal tunnel function injury than to have renal glomerular function injury.Urinary IgG and urinary TRF are more sensitive than urinary MA in indicating the injury of renal glomerular function in patients with SLE.Urinary β 2-MG and urinary o 1-MG are more sensitive than urinary NAG in indicating the injury of renal tunnel function in patients with SLE.
出处
《国际医药卫生导报》
2013年第21期3338-3342,共5页
International Medicine and Health Guidance News
