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贝伐珠单抗治疗放射性脑损伤的临床观察 被引量:6

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摘要 放疗作为头颈部肿瘤的主要治疗手段,对肿瘤周围脑组织也造成不同程度的损伤。既往研究报道,放射后脑损伤的发生率达4.6%~35%,与放疗方案和个体因素有关”。放射性脑损伤的临床表现主要是脑水肿所致的颅内压增高和坏死脑组织所致的定位症状或体征。传统治疗方案是脱水联合免疫抑制剂(如糖皮质激素),但其有效率仅为20%左右。长期使用糖皮质激素可引发一系列不良反应,如代谢紊乱、胃肠道出血及因免疫抑制而合并感染等。
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2013年第5期563-565,共3页 Chinese Journal of Radiological Medicine and Protection
基金 国家自然科学基金(81072242,81272576)
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