摘要
目的探讨CT灌注成像(CTPI)在重型颅脑外伤中的应用价值。方法 41例重型脑外伤患者,对病灶进行CT灌注扫描,分析病灶区的CTPI参数:局部脑血流量(rCBF)、局部脑血容量(rCBV)和平均通过时间(rMTT),并与对侧进行比较。以rCBV≤2ml/100g作为脑灌注不良阈值,记录大脑发生灌注不良区域的数目,并与3个月后格拉斯哥预后评分(GOS)进行综合分析。结果重型颅脑外伤后,损伤区普遍发生脑灌注降低,表现为rCBF、rCBV降低,rMTT升高(P<0.05)。随着大脑发生严重低灌注区域数量的增多,临床预后有明显降低(P<0.05)。在普通CT显示的低密度区,92.1%CTPI出现了低灌注,7.9%出现灌注增高。结论对重型颅脑外伤使用CTPI检查有助于了解局部脑组织血流灌注情况,为治疗和预后判断提供依据。
Objective To investigate the value of CT perfusion imaging（CTP1） in evaluating severe traumatic brain injury（sTBI）. Methods CTPI and regular CT scan were performed in 41 patients with sTBI. Regular CT findings and CTPI were evaluated together with Glasgow Outcome Scale（COS） score in the 3rd month. Results Cerebral hypofusion in sTBI patients was a common phenomenon, which was characterized by low values of regional cerebral blood flow（rCBF） and regional cerebral blood volumn （rCBV） and a significant prolongation of region mean transit time （rMTT） （P〈0. 05）. The number of hypofusion area involved in brain tissues had significant relationship with COS scores. In the areas showing low density on regular CT scan, hypofusion accounted for 92. 1% on CTPI and hyperfusion for 7.9%. Conclusion CTPI is helpful in understanding regional cerebral blood perfusion in the patients with sTBI, which provides the evidences in the treatment and prognosis prediction.
出处
《江苏医药》
CAS
北大核心
2013年第20期2429-2431,共3页
Jiangsu Medical Journal
关键词
1CT灌注成像
颅脑外伤
CT perfusion imaging
Traumatic brain injury
